| Japanese |
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| Title | 虚血性心疾患の運動負荷心筋シンチグラフィにおける99mTc-MIBI心筋washout |
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| Subtitle | 原著 |
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| Authors | 外山卓二*,****, 西村恒彦*,***, 植原敏勇*,***, 下永田剛*, 林田孝平*, 石田良雄*, 野々木宏**, 土師一夫** |
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| Authors(kana) | |
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| Organization | *国立循環器病センター放射線診療部, **心臓内科, ***大阪大学医学部トレーサ情報解析学, ****群馬大学医学部第二内科学教室 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 6 |
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| Page | 559-564 |
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| Year/Month | 1994/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」新しい心筋血流イメージング製剤であるTc-99m hexakis-2-methoxy isobutyl isonitrile(MIBI)の心筋washoutを23例の冠動脈疾患で, 運動負荷1時間後および3時間後像を撮像し検討した. 症例は労作性狭心症8例(AP群), 201Tl運動負荷心筋シンチグラフィでreversible defectを認めた心筋梗塞6例(MI-RD(+)群), reversible defectを認めなかった心筋梗塞9例(MI-RD(-)群)の3群に分割した. AP群においてwashout rateは正常域8.3±5.6%であり, 虚血域(3.8±7.5%)では有意に低値であった(p<0.05). しかし他の2群には有意差を認めなかった. defect/normal比はAP群およびMI-RD(+)群で3時間後像が1時間後像よりやや上昇傾向を示した. 99mTc-MIBIは虚血域において運動負荷後軽度再分布が認められることから, その読影上注意を要することが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MIBI, Exercise myocardial scintigraphy, Ischemic heart disease, Washout rate. |
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| English |
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| Title | Myocardial Washout of 99mTc-Hexakis-2-Methoxy Isobutyl Isonitrile (99mTc-MIBI) at Exercise Myocardial Scintigraphy in Patients with Ischemic Heart Disease |
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| Subtitle | Original Articles |
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| Authors | Takuji TOYAMA*,****, Tsunehiko NISHIMURA*,***, Toshiisa UEHARA*,***, Tsuyoshi SHIMONAGATA*, Kohei HAYASHIDA*, Yoshio ISHIDA*, Hiroshi NONOGI**, Kazuo HAZE** |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, **Division of Cardiology, National Cardiovascular Center, ***Department of Tracer Kinetics, Osaka University School of Medicine, ****Second Department of Internal Medicine, Gunma University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 6 |
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| Page | 559-564 |
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| Year/Month | 1994/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Myocardial washout of the new myocardial perfusion imaging agent, 99mTc-hexakis-2-methoxy isobutyl isonitrile (99mTc-MIBI) was studied in 23 patients with coronary artery disease. These patients were divided into three groups; 8 patients with effort angina pectoris (AP group), 6 with myocardial infarction who had reversible defect (MI-RD (+) group) and 9 with myocardial infarction who had not reversible defect (MI-RD (-) group). Regional radioactivities were determined with postexercise 1-and 3-hour myocardial planar images. In AP group, 99mTc-MIBI washout rate in ischemic area was smaller than in normal area (3.8+-7.5% vs. 8.3+-5.6%, p<0.05), however, in the remaining two groups, there were no difference in washout between normal and infarct areas. Defect/normal ratios from postexercise 1 hour to 3 hours were slightly increased in AP and MI-RD (+) groups. Our results indicate that 99mTc-MIBI showed slight and incomplete myocardial redistribution in ischemic areas. These data showed to be considered in the interpretation of 99mTc-MIBI myocardial imaging. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MIBI, Exercise myocardial scintigraphy, Ischemic heart disease, Washout rate. |
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