Japanese
Title虚血性心疾患の運動負荷心筋シンチグラフィにおける99mTc-MIBI心筋washout
Subtitle原著
Authors外山卓二*,****, 西村恒彦*,***, 植原敏勇*,***, 下永田剛*, 林田孝平*, 石田良雄*, 野々木宏**, 土師一夫**
Authors(kana)
Organization*国立循環器病センター放射線診療部, **心臓内科, ***大阪大学医学部トレーサ情報解析学, ****群馬大学医学部第二内科学教室
Journal核医学
Volume31
Number6
Page559-564
Year/Month1994/6
Article原著
Publisher日本核医学会
Abstract「要旨」新しい心筋血流イメージング製剤であるTc-99m hexakis-2-methoxy isobutyl isonitrile(MIBI)の心筋washoutを23例の冠動脈疾患で, 運動負荷1時間後および3時間後像を撮像し検討した. 症例は労作性狭心症8例(AP群), 201Tl運動負荷心筋シンチグラフィでreversible defectを認めた心筋梗塞6例(MI-RD(+)群), reversible defectを認めなかった心筋梗塞9例(MI-RD(-)群)の3群に分割した. AP群においてwashout rateは正常域8.3±5.6%であり, 虚血域(3.8±7.5%)では有意に低値であった(p<0.05). しかし他の2群には有意差を認めなかった. defect/normal比はAP群およびMI-RD(+)群で3時間後像が1時間後像よりやや上昇傾向を示した. 99mTc-MIBIは虚血域において運動負荷後軽度再分布が認められることから, その読影上注意を要することが示唆された.
Practice臨床医学:一般
Keywords99mTc-MIBI, Exercise myocardial scintigraphy, Ischemic heart disease, Washout rate.
English
TitleMyocardial Washout of 99mTc-Hexakis-2-Methoxy Isobutyl Isonitrile (99mTc-MIBI) at Exercise Myocardial Scintigraphy in Patients with Ischemic Heart Disease
SubtitleOriginal Articles
AuthorsTakuji TOYAMA*,****, Tsunehiko NISHIMURA*,***, Toshiisa UEHARA*,***, Tsuyoshi SHIMONAGATA*, Kohei HAYASHIDA*, Yoshio ISHIDA*, Hiroshi NONOGI**, Kazuo HAZE**
Authors(kana)
Organization*Department of Radiology and Nuclear Medicine, **Division of Cardiology, National Cardiovascular Center, ***Department of Tracer Kinetics, Osaka University School of Medicine, ****Second Department of Internal Medicine, Gunma University School of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume31
Number6
Page559-564
Year/Month1994/6
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Myocardial washout of the new myocardial perfusion imaging agent, 99mTc-hexakis-2-methoxy isobutyl isonitrile (99mTc-MIBI) was studied in 23 patients with coronary artery disease. These patients were divided into three groups; 8 patients with effort angina pectoris (AP group), 6 with myocardial infarction who had reversible defect (MI-RD (+) group) and 9 with myocardial infarction who had not reversible defect (MI-RD (-) group). Regional radioactivities were determined with postexercise 1-and 3-hour myocardial planar images. In AP group, 99mTc-MIBI washout rate in ischemic area was smaller than in normal area (3.8+-7.5% vs. 8.3+-5.6%, p<0.05), however, in the remaining two groups, there were no difference in washout between normal and infarct areas. Defect/normal ratios from postexercise 1 hour to 3 hours were slightly increased in AP and MI-RD (+) groups. Our results indicate that 99mTc-MIBI showed slight and incomplete myocardial redistribution in ischemic areas. These data showed to be considered in the interpretation of 99mTc-MIBI myocardial imaging.
PracticeClinical medicine
Keywords99mTc-MIBI, Exercise myocardial scintigraphy, Ischemic heart disease, Washout rate.

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