| Japanese |
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| Title | 前立腺癌の骨転移におけるEarly Whole Body骨シンチグラフィの有用性について |
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| Subtitle | 原著 |
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| Authors | 大塚信昭*, 福永仁夫*, 古川洋二**, 田中啓幹** |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学科, **泌尿器科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 6 |
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| Page | 541-550 |
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| Year/Month | 1994/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」25例の前立腺癌患者(骨転移15例, 骨転移なし10例)に, 99mTc-HMDPによる投与後の5分目に前面および後面の全身像を得るEarly whole body骨シンチグラフィを施行し, 3時間後の通常の骨シンチグラフィ所見と比較し, 骨転移診断におけるその有用性を検討した. 通常の骨シンチグラフィ上, 下部腰椎に集積亢進がみられるが, Early whole body骨シンチグラフィ上異常を認めない症例では骨X線上spondylosis deformanceなどの老人性骨変化が観察された. 多発性骨転移例においてはEarly whole body骨シンチグラフィも通常の骨シンチグラフィの双方に多発性の異常集積が認められた. また, Super bone scanを呈した症例はEarly whole body骨シンチグラフィにてもすでに躯幹骨への高集積を認めた. なお, 多発性骨転移例9例における治療前後の経過をEarly whole body骨シンチグラフィと腫瘍マーカー(prostatic specific antigen, γ-semino protein, prostatic acid phosphatase)の変動から検討すると進行例4例中3例ではEarly whole body骨シンチグラフィ上の集積亢進と新たなhot spotsの出現と腫瘍マーカーの上昇を認め, 改善例5例では集積の低下, 腫瘍マーカーの低下, 正常化を認めた. |
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| Practice | 臨床医学：一般 |
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| Keywords | The Usefulness of Early Whole Body Bone Scintigraphy in the Detection of Bone Metastasis from Prostatic Cancer |
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| English |
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| Title | The Usefulness of Early Whole Body Bone Scintigraphy in the Detection of Bone Metastasis from Prostatic Cancer |
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| Subtitle | Original Articles |
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| Authors | Nobuaki OTSUKA*, Masao FUKUNAGA*, Yohji FURUKAWA**, Hiroyoshi TANAKA** |
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| Authors(kana) | |
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| Organization | *Division of Nuclear Medicine, Department of Radiology, **Department of Urology, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 6 |
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| Page | 541-550 |
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| Year/Month | 1994/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Early whole body bone scintigraphy was performed on 25 patients with prostatic cancer (15 cases with bone metastases and 10 cases without bone metastasis) to obtain anterior and posterior whole body images five minutes after administration of 99mTc-HMDP. The results were compared with the findings of routine bone scintigraphy after three hours, and the usefulness of the above method for the diagnosis of bone metastasis from prostatic cancer was evaluated. In cases in which increased activity was found in the upper and lower lumbar vertebrae by routine bone scintigraphy but no abnormality was seen by early whole body bone scintigraphy, senile degenerative bone changes such as spondylosis deformans were observed by bone radiography. In cases with multiple bone metastases, abnormal multiple accumulations were found by both early whole body bone scintigraphy and routine bone scintigraphy. In addition, in cases showing super bone scan, high accumulation in the skeletal system had already been detected by early whole body bone scintigraphy. When the courses before and after treatment in nine cases of multiple bone metastases were passaged from the results of early whole body bone scintigraphy and from changes in tumor markers (prostatic specific antigen, γ-semino protein and prostatic acid phosphatase), increased activity and the appearance of new hot spots as well as an increase in tumor markers were detected by early whole body scintigraphy in three of the four advanced cases, whereas decreased accumulations and a decrease in and normalization of tumor markers were observed in five improved cases. |
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| Practice | Clinical medicine |
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| Keywords | Early whole body bone scintigraphy, Prostatic cancer, Bone metastasis. |
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