| Japanese |
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| Title | 肝臓の生理と機能診断 |
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| Subtitle | 総説 |
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| Authors | 山本和高* |
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| Organization | *福井医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 5 |
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| Page | 521-526 |
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| Year/Month | 1994/5 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肝内占拠性病変の診断を目的としたコロイド肝シンチグラフィの臨床的有用性は低下したが, 核医学検査は肝腫瘤の性状診断, 治療効果の判定などに有用であり, 免疫シンチグラフィで転移性肝癌の描出も可能になってきている. 99mTc galactosyl serum albumin(GSA)は肝細胞にのみ存在するアシアロ糖タンパク受容体に選択的に結合し, 肝機能を定量的に評価することができる新しい放射性医薬品であり, 他の画像検査法では診断できない局所的な肝機能異常も評価できる可能性がある. PETではブドウ糖, アミノ酸など生体の主要な物質と化学的にまったく同一のトレーサを利用でき, しかも分解能の良好な, 定量性の高いデータを得られるので, 肝臓の真の生理的, 生化学的機能を明らかにできると考えられ, 今後の研究成果が期待される. 「はじめに」日本アイソトープ協会の調査によれば, 1982年には「肝・胆道」のインビボ核医学検査件数は年間416,000件と推定され, もっとも多い検査項目であったが, 1992年には75,800件と激減している. |
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| Practice | 臨床医学：一般 |
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| Keywords | Liver scintigraphy, Liver function, Liver tumor, 99mTc-GSA, PET. |
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| English |
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| Title | Nuclear Medicine for Evaluation of Liver Functions |
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| Subtitle | |
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| Authors | Kazutaka YAMAMOTO |
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| Authors(kana) | |
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| Organization | Department of Radiology, Fukui Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 5 |
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| Page | 521-526 |
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| Year/Month | 1994/5 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The clinical usefulness of colloid liver scintigraphy to detect space occupying lesions in the liver has been reduced by X-ray CT and ultrasonography. However, scintigraphic examinations have potentials for characteristic diagnosis of liver tumors, such as 99mTc RBC SPECT for hepatic hemangioma, 99mTc PMT for positive imaging of hepatocellular carcinoma and its extrahepatic metastasis, and radioimmunoscintigraphy for metastatic tumors. Moreover, prediction of the prognosis and monitoring therapeutic effect to liver cancer can be made by the use of nuclear medicine techniques. Recently, 99mTc galactosyl serum albumin (GSA), a newly developed radiotracer to evaluate hepatocyte function, has become commercially available. Quantitative parameters of liver functions can be obtained by analysis of time-activity curve in blood and liver after 99mTc-GSA administration. In several cases, 99mTc-GSA study showed intrahepatic unevenness of function, which could not be depicted by other imaging examinations. Positron emission tomography (PET) with 18F-fluoro-2-deoxy glucose (FDG) is useful to detect malignant tumors in the liver. Since PET can provide absolutely quantitative data in better resolution, it is expected that regional true metabolic functions in the liver may be able to be quantitatively evaluated with PET in near future. |
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| Practice | Clinical medicine |
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| Keywords | Liver scintigraphy, Liver function, Liver tumor, 99mTc-GSA, PET. |
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