| Japanese |
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| Title | 抗癌剤療法例における123I-MIBG心シンチグラフィ |
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| Subtitle | 原著 |
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| Authors | 小野恵*, 高橋恒男* |
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| Organization | *岩手医科大学放射線医学講座 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 5 |
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| Page | 451-458 |
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| Year/Month | 1994/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」抗癌剤投与患者の心毒性について123I-MIBG心交感神経イメージングを用いて検討した. 症例は抗癌剤多剤併用療法を受けた7〜67歳まで(平均年齢49.6歳, 男性11例, 女性8例)の合計19症例で, 初期像および後期像(Planar, SPECT像)からrelative regional uptake(RRU), wash out ratio(W/O)を求め, さらに前壁, 側壁, 下壁, 中隔の4つの区域に分けて検討した. アドリアマイシン総量とW/Oとの相関はなかったが, 各薬剤の総投与量が多いほどW/Oが高値を示す傾向にあり, 特に下, 側壁に著明であった. また下壁領域のRRUの低下は特徴的であり, 18F-FDG PETイメージングにてこの領域の心筋糖代謝の低下が確認され, 抗癌剤心毒性の影響が考えられた. 201Tl心筋シンチグラフィの所見とは一致せず, 99mTc-HSA-D心プールシンチグラフィにて測定された左室駆出率も正常であり, 抗癌剤心毒性の早期検出に123I-MIBG心交感神経イメージングの有用性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-MIBG image, Cardiotoxicity, Antineoplastic agents. |
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| English |
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| Title | 123I-MIBG Scintigraphy in Cardiotoxicity Related to Antineoplastic Agents |
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| Subtitle | Original Articles |
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| Authors | Megumi ONO, Tsuneo TAKAHASHI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Iwate Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 5 |
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| Page | 451-458 |
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| Year/Month | 1994/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The purpose of this study is to determine the value of 123I-MIBG scintigraphy to evaluate cardiotoxic effects of antineoplastic agents. We performed 123I-MIBG scintigraphy in 19 patients with malignant neoplasms treated with multiagent chemotherapy including adriamycin. Based on the initial and delayed myocardial images (planar and SPECT), segmental myocardial uptake and washout ratio of MIBG were obtained. Low uptake in the myocardium and rapid wash-out from the myocardium especially in the lateral and inferior segments, were noted in patients with cardiotoxicity. Such cardiotoxic effect is dose-dependent. This abnormal areas corresponded to decreased glucose metabolism observed by 18F-FDG PET images. This was suggestive of mitochondrial dysfunction or myocardial damage. There was mismatch in the defect when compared to the result of 201Tl perfusion scintigraphy, and LVEF obtained failed to demonstrate abnormalities. Therefor, 123I-MIBG scintigraphy may be an useful measure in detecting cardiotoxicity related to antineoplastic agents in early stage. |
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| Practice | Clinical medicine |
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| Keywords | 123I-MIBG image, Cardiotoxicity, Antineoplastic agents. |
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