| Japanese |
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| Title | 全脳血流量と脳血流トレーサを用いた局所脳血流量測定 : 健常例における123I-IMPおよび99mTc-HMPAO SPECT脳血流量比較 |
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| Subtitle | 原著 |
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| Authors | 井坂吉成*,**, 今泉昌利**, 蘆田敬一**, 大江洋介**, 岡本昌也**, 阿部亨**, 田中清次* |
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| Organization | *国立大阪病院画像診断部, **総合内科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 5 |
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| Page | 423-429 |
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| Year/Month | 1994/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」健常例9例において, 133Xe全脳平均血流量測定後123I-IMPあるいは99mTc-HMPAOを静注しSPECT局所脳血流量イメージングを2度行い, 脳20関心領域において局所脳血流量を比較した. IMP局所脳血流量は, HMPAOと比較して, 線条体にて有意に低かった. 逆にHMPAO局所脳血流量は前葉頭, 右後頭葉などの皮質灰白質高血流部でIMP局所脳血流量よりも有意に低く, 小脳, 白質で有意に高かった. IMP脳血流量, HMPAO脳血流量の相関は皮質灰白質(rs=0.761;p<0.001), 白質(rs=0.739;p<0.001), 小脳(rs=0.731;p<0.001)において高かったが, 線条体(rs=0.58;p<0.05), 視床(rs=0.628;p<0.01)では前3者と比較して低かった. 高血流部におけるトレーサの逆拡散によりHMPAOイメージはIMPと比較してコントラストが低下すると考えられるが, この仮説のみではIMPとHMPAOの脳取り込み程度の違いをすべて説明することはできない. IMP-SPECTとHMPAO-SPECTは主として脳血流分布を反映するが, 両者の局所血流分布の乖離にはトレーサの特性に加えて脳局所因子が関係していると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cerebral blood flow, 123I-IMP, 99mTc-HMPAO, Striatum, Cerebellum. |
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| English |
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| Title | Quantitation of Regional Cerebral Blood Flow by Single Photon Emission Computed Tomography of CBF-Tracer Combined with Whole-Brain CBF : A Comparison between 123I-IMP and 99mTc-HMPAO in Healthy Volunteers |
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| Subtitle | Original Articles |
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| Authors | Yoshinari ISAKA*,**, Masatoshi IMAIZUMI**, Keiichi ASHIDA**, Yosuke OHE**, Masaya OKAMOTO**, Tohru ABE**, Seiji TANAKA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine,, **Department of Internal Medicine, Osaka National Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 5 |
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| Page | 423-429 |
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| Year/Month | 1994/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A simple, noninvasive method of measuring cerebral blood flow (CBF) that uses single-photon emission computed tomography (SPECT) of CBF-tracer and whole brain CBF obtained by xenon-133 (133Xe) clearance technique was developed. In nine healthy volunteers, SPECT data were normalized to the count density of 123I-IMP or 99mTc-HMPAO uptake in the whole-brain, and then converted to the absolute units of CBF by multiplying average 133Xe-CBF in the whole brain. The CBF values measured by 99mTc-HMPAO CBF-SPECT was significantly lower in the high flow regions of cortical gray matter (bilateral frontal lobe; p<0.05 and right occipital lobe; p<0.05), and was significantly higher in the bilateral white matter (p<0.05 or 0.01) and the cerebellum (p<0.005) compared with the flow values measured by 123I-IMP CBF-SPECT. Whereas, the IMP-CBF values were significantly lower in the bilateral striatum (p<0.02 or 0.05) compared with the HMPAO-CBF values. Good correlations were found between IMP-CBF and the HMPAO-CBF values in the cortical gray matter (rs=0.761; p<0.001, n=108), the white matter (rs=0.739; p<0.001, n=18) and the cerebellum (rs=0.731; p<0.001, n=18). In the striatum (rs=0.58; p<0.05, n=18) and the thalamus (rs=0.628; p<0.05, n=18), the correlations between IMP-CBF and HMPAO-CBF values were inferior to those of the other three regions. The results indicated that the contrast between high and low CBF regions in the HMPAO CBF-SPECT was significantly less than that in the IMP CBF-SPECT. However, this assumption is not applicable in all of the cerebral regions. |
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| Practice | Clinical medicine |
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| Keywords | Cerebral blood flow, 123I-IMP, 99mTc-HMPAO, Striatum, Cerebellum. |
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