| Japanese |
|---|
| Title | 拡張型心筋症における123I-MIBG心筋SPECTの臨床的意義 |
|---|
| Subtitle | 短報 |
|---|
| Authors | 山崎純一*, 細井宏益*, 山科久代*, 蒲野俊雄*, 山科昌平*, 南條修二*, 松川星四郎*, 森下健*, 岡本淳**, 大沢秀文** |
|---|
| Authors(kana) | |
|---|
| Organization | *東邦大学医学部付属大森病院内科学第一講座, **付属佐倉病院内科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 31 |
|---|
| Number | 4 |
|---|
| Page | 373-377 |
|---|
| Year/Month | 1994/4 |
|---|
| Article | 報告 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」 βブロッカー療法中の拡張型心筋症 (DCM) を対象に, MIBG心筋SPECTを施行し, 得られた画像と心エコー図から算出した心機能の変化を比較検討した. 対象は厚生省診断の手引きに基づき, 確定診断したDCM男性7例 (57.7±10.2歳) である. MIBGを111MBq (3 mCi) 静注し, 20分後と4時間後に心筋SPECTを撮像した. 左室全周のwashout rateはLVEFが10%以上改善した群 (A群:n=4) の30.3±6.1%に比較し, 10%末満に留まった不変群 (B群:n=3) は40.7±1.2%と有意に (P<0.05) 高値が示された. B群では初期像, 遅延像ともextent, severity scoreはA群に比し高い傾向が示された. LVEFとwashout rateの間にr=-0.819 (P<0.05) の相関関係が得られた. またβブロッカー療法前後でのLVEFの変化率とwashout rateの間にr=-0.969 (P<0.01) の相関関係が得られた. 以上より, MIBG心筋SPECTはDCMの重症度評価や予後判定に有用である可能性が示唆された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 123I-MIBG myocardial SPECT, Dilated cardiomyopathy, Nipradilol (β blocker) . |
|---|
| English |
|---|
| Title | Clinical Meaning of 123I-MIBG Myocardial SPECT in Patients with Dilated Cardiomyopathy |
|---|
| Subtitle | Short Communications |
|---|
| Authors | Junichi YAMAZAKI*, Hiromitsu HOSOI*, Hisayo YAMASHINA*, Toshio KABANO*, Shohei YAMASHINA*, Shuji NANJO*, Seishiro MATSUKAWA*, Takeshi MORISHITA*, Kiyoshi OKAMOTO**, Hidefumi OHSAWA** |
|---|
| Authors(kana) | |
|---|
| Organization | *First Department Internal Medicine, Ohmori Hospital, Toho University School of Medicine, **Internal Medicine, Sakura Hospital, Toho University School of Medicine |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 31 |
|---|
| Number | 4 |
|---|
| Page | 373-377 |
|---|
| Year/Month | 1994/4 |
|---|
| Article | Report |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] MIBG-myocardial SPECT was performed on patients with dilated cardiomyopathy (DCM) undergoing treatment with β blocker (Nipradilol) . The findings of MIBG-myocardial SPECT were compared with the changes in cardiac function obtained by echocardiograms. The patients enrolled in the study were seven males who has been diagnosed as definitely suffering from DCM according to diagnostic guidelines provided by the Ministry of Health and Welfare. The patients were aged 57.5+-10.2 years. Following intravenous administration of 111 MBq (3 mCi) of MIBG, myocardial SPECT was taken 20 minutes, and 4 hours later. The washout rate of the left ventricular wall was higher in the unchanged group (40.7+-1.2%) than in the improved group (30.3+-6.1%) . Both the early and delayed images showed higher extent and severity scores for the unchanged group than for the improved group. A correlation of LVEF with the washout rates was demonstrated (r=-0.819, p<0.05) . A correlation was also observed between the variations in LVEF before and after β blocker therapy with the washout rates (r=-0.969, p<0.01) , MIBG-myocardial SPECT suggested possibility of the evaluation of severity and prognosis in the patients with DCM. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 123I-MIBG myocardial SPECT, Dilated cardiomyopathy, Nipradilol (β blocker) . |
|---|