| Japanese |
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| Title | 99mTc-HMPAOを用いた脳血流の簡便な定量的評価法によるDIAMOX負荷前後での脳血流評価 |
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| Subtitle | 短報 |
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| Authors | 寺田一志*,***, 渡邊徳明**, 五味達哉***, 村上省吾***, 長基雅司***, 桑島章***, 平松慶博***, 岩渕聡**, 牛久保行男**, 鮫島寛次**, 吉井信夫**, 松田博史**** |
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| Authors(kana) | |
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| Organization | *東京女子医科大学脳神経センター神経放射線科, **東邦大学医学部第二脳神経外科, ***第二放射線科, ****国立精神・神経センター武蔵病院放射線診療部 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 4 |
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| Page | 367-371 |
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| Year/Month | 1994/4 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Patlak Plot法と99mTc-HMPAOを用いた非侵襲的で簡便な脳血流の定量評価法により, Acetazolamide (DIAMOX(R)) 負荷による脳血流増加をとらえ得るか検討した. 99mTc-HMPAO SPECTを施行するに際しRIアンジオグラフィを撮像し, Patlak Plot法により脳への流入速度定数 (ku) および非特異的に脳内に存在し血中の放射能と速い平衡にあるトレーサの分布容積 (Vn) を求め, それぞれを関心領域の大きさで補正した指標 (Brain Perfusion Index, BPIおよびCorrected Vn, Corr. Vn) を算出した. baseline studyの結果post-DIAMOX studyが必要とされた9名を対象とし, baseline studyの約1週間後にpost-DIAMOX studyを施行した. その結果DIAMOX負荷時のBPIはbaseline studyに対し平均で25.8%の増加が見られ, DIAMOX負荷時のCorr. Vnはbaseline studyに対し平均で23.5%の増加が見られた. 各症例のBPIの増加率とCorr. Vnの増加率の間には正の相関 (r=0.795) が見られた. 以上より本法により非侵襲的かつ簡便に, DIAMOX負荷による脳血流の増加が確認できると考えられた. またBPIとCorr. Vnの増加率の間に正の相関が見られたことから, DIAMOXが末梢の脳血管を拡張させ脳血流が増加している可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-HMPAO, Radionuclide angiography, Graphical analysis, Brain perfusion, Acetazolamide. |
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| English |
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| Title | A Quantitative Approach to the rCBF Response to Acetazolamide Using 99mTc-HMPAO and Graphical Analysis |
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| Subtitle | Short Communications |
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| Authors | Hitoshi TERADA*,***, Noriaki WATANABE**, Tatsuya GOMI***, Shogo MURAKAMI***, Masashi NAGAMOTO***, Akira KUWAJIMA***, Yoshihiro HIRAMATSU***, Satoshi IWABUCHI**, Yukio USHIKUBO**, Hirotsugu SAMEJIMA**, Nobuo YOSHII**, Hiroshi MATSUDA**** |
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| Authors(kana) | |
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| Organization | *Department of Neuroradiology, Neurological Institute, Tokyo Women's Medical College, **Second Department of Neurosurgery, Toho University School of Medicine, ***Second Department of Radiology, Toho University School of Medicine, ****Division of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 4 |
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| Page | 367-371 |
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| Year/Month | 1994/4 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A simple noninvasive method for a quantitative measurement of brain perfusion is presented using intravenous radionuclide angiography with 99mTc-hexamethylpropylene amine oxime (HMPAO) . Graphical analysis was employed for the evaluation of the unidirectional influx constant (ku) of the tracer from the blood to the brain and the initial distribution volume (Vn) for the tracer, which is the volume of the exchangeable region plus the plasma space. The ku and Vn values were standardized to provide objective and comparable values, brain perfusion indices (BPI) and corrected Vn (Corr. Vn) , between subjects by setting the size ratio of ROIbrain to ROIaorta at 10 and 1, respectively. BPI and Corr. Vn of the whole brain were measured before and 20 min after injection of 1 g acetazolamide. After acetazolamide administration, BPI and Corr. Vn increased in all eight subjects with cerebrovascular diseases and one with a pituitary adenoma, by a mean of×1.26 and 1.24, respectively. Increase of BPI showed a significant correlation with increase of Corr. Vn. This technique is easy to apply as an adjunct to SPECT and may be helpful in the measurement of brain perfusion changes in the acetazolamide test. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-HMPAO, Radionuclide angiography, Graphical analysis, Brain perfusion, Acetazolamide. |
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