Japanese
Title123I-metaiodobenzylguanidine心筋イメージングの定量評価 - 心不全における検討 -
Subtitle原著
Authors成田充啓*, 栗原正*, 村野謙一*, 宇佐美暢久*, 本田稔**
Authors(kana)
Organization*住友病院内科, **アイソトープ検査部
Journal核医学
Volume31
Number4
Page347-358
Year/Month1994/4
Article原著
Publisher日本核医学会
Abstract「要旨」123I-metaiodobenzylguanidine (123I-MIBG) 心筋イメージングにおける123I-MIBGの心筋への取り込みの定量評価の有用性を, 健常9例, 心不全18例で検討した. 123I-MIBG (初期像, 遅延像) および201Tl心筋イメージングを安静時に施行, 前面プラナー像より上縦隔 (M) と心臓 (H) でのアイソトープ比 (H/M) を, 全身像より注入アイソトープに対して心臓に取り込まれたアイソトープの比率 (%Uptake) を求めた. 遅延像における123I-MIBGのH/Mは心不全例と健常例の鑑別に有用であった. 123I-MIBGの%Uptakeは健常例と心不全を区別し得なかったが, 心筋血流量 (201Tlの%Uptake) で補正した123I-MIBGの%Uptake (Uptake Ratio) は, ことに遅延像で, H/M同様に心不全と健常例を区別しうる指標であった. 遅延像でのUptake Ratioや123I-MIBGのH/Mを201TlのH/Mで除したH/M Ratioは心機能 (%FS, 左室駆出率) や血中norepinephrineレベルをよく反映し, Uptake Ratioは123I-MIBG取り込みの有用な指標と考えられた.
Practice臨床医学：一般
Keywords123I-MIBG myocardial imaging, Congestive heart failure, H/M (Heart to Mediastinal Ratio) , %Uptake, Uptake Ratio.
English
TitleQuantitative Analysis of 123I-Metaiodobenzylguanidine Myocardial Imaging : Assessment of Its Usefulness in Patients with Congestive Heart Failure
SubtitleOriginal Articles
AuthorsMichihiro NARITA*, Tadashi KURIHARA*, Kenichi MURANO*, Masahisa USAMI*, Minoru HONDA**
Authors(kana)
Organization*Department of Internal Medicine, Sumitomo Hospital, **Department of Nuclear Medicine, Sumitomo Hospital
JournalThe Japanese Journal of nuclear medicine
Volume31
Number4
Page347-358
Year/Month1994/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] To investigate the usefulness of the quantitative analysis of 123I-metaiodobenzylguanidine (123I-MIBG) myocardial uptake, we studied 9 normal subjects and 18 patients with congestive heart failure (CHF) . Rest myocardial imaging with 123I-MIBG was performed at 20 minutes and 3 hours (delayed image) after 123I-MIBG injection. Rest 201Tl imaging was obtained at 20 minutes after 201Tl injection. In addition to ordinary tomograms, a planar anterior image and a whole body image were supplemented in each imaging. In patients with CHF fractional shortening (%FS) was calculated from echocardiography and left ventricular ejection fraction was obtained from cardiac blood pool imaging with 99mTc at rest. We calculated H/M (heart to mediastinum count ratio) from the anterior planar image and %Uptake (percentage of cardiac uptake of the isotope to total injected dose) from the whole body image. H/M of 123I-MIBG in delayed images separated patients with CHF from normal subjects (2.00+-0.19 vs. 2.56+-0.13, P<0.01) . H/M Ratio (H/M of 123I-MIBG devided by H/M of 201Tl) in delayed image could distinguish these two groups poorly (0.72+-0.12 vs. 0.88+-0.14, p<0.05) . On the other hand, %Uptake of 123I-MIBG was not different between two groups (3.49+-0.60% in CHF, 3.54+-0.34% in normal) . But %Uptake of 201Tl was greater in CHF than in normal (5.96+-1.09% vs. 4.70+-0.30%, p<0.05) . When myocardial 123I-MIBG uptake was normalized by myocardial perfusion (%Uptake of 123I-MIBG divided by %Uptake of 201Tl, Uptake Ratio) , Uptake Ratio in delayed image could distinguish theses two groups as sams as H/M (0.60+-0.05 in CHF, 0.75+-0.05 in normal, p<0.01) . In patients with CHF, H/M of 123I-MIBG did not reflect LV function and serum norepinephrine (NE) level. But Uptake Ratio and H/M Ratio in delayed image correlated well with %FS (r=0.88, r=0.65) , EF (r=0.80, r=0.68) and NE level (r=-0.77, r=-0.75) . Although the calculation of Uptake Ratio is time consuming and expensive, it was assumed that Uptake Ratio is an useful index to quantitate myocardial 123I-MIBG uptake.
PracticeClinical medicine
Keywords123I-MIBG myocardial imaging, Congestive heart failure, H/M (Heart to Mediastinal Ratio) , %Uptake, Uptake Ratio.

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