| Japanese |
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| Title | Microsphere modelを用いたN-isopropyl-p-[123I]iodoamphetamine (IMP) による局所脳血流定量法の問題点 - 133Xe SPECTおよび経時的123I-IMP SPECTとの比較検討 - |
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| Subtitle | 原著 |
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| Authors | 高橋直也*, 大久保真樹**, 小田野行男*, 大滝広雄***, 野口栄吉***, 山崎芳裕***, 羽田野政義***, 酒井邦夫* |
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| Authors(kana) | |
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| Organization | *新潟大学医学部放射線医学教室, **新潟大学医療技術短期大学放射線技術学科, ***新潟大学医学部附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 4 |
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| Page | 319-326 |
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| Year/Month | 1994/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 中枢神経疾患に対し123I-IMPとmicrosphere modelを用いて局所脳血流量 (rCBF) を求め, 133Xe吸入SPECTによって求めたrCBFと比較した. microsphere modelでは, 静注後5分間の持続採血動脈血を入力関数とした. 25分後から30分間かけて撮像したSPECTは5分, 20分, 60分時の頭部全体の放射能の比を用いて補正し, 5分後の再構成カウントを推定した. 得られたrCBFは, 133Xeから求めたrCBFと比較し, 高血流域で過小, 低血流域で過大に評価された. 123I-IMPの静注5分, 20分, 60分後の1分間の短時間SPECTからそれぞれ算出したrCBFは, 20分で15-30%, 60分で30-60%少ない値を示し, 洗い出しの存在が確認された. 平衡時のSPECTのrCBFを早期のSPECTのrCBFと比較すると, 高血流域で過小に, 低血流域で過大に評価された. これは, 高血流域と低血流域で123I-IMPの挙動が異なるにも関わらず, 頭部全体の放射能で平衡時のSPECTを補正することにより生じた誤差であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, Single photon emission computed tomography, rCBF measurement, Microsphere model, Distribution volume. |
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| English |
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| Title | A Problem of Quantitative Measurement of Regional Cerebral Blood Flow Using Microsphere Model and N-isopropyl-p-[123I]iodoamphetamine (IMP) : Comparison with 133Xe SPECT and Sequential Dynamic 123I-IMP SPECT |
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| Subtitle | Original Articles |
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| Authors | Naoya TAKAHASHI*, Masaki OHKUBO**, Ikuo ODANO*, Hiroo OHTAKI***, Eikichi NOGUCHI***, Yoshihiro YAMAZAKI***, Masayoshi HATANO***, Kunio SAKAI* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Niigata University School of Medicine, **Department of Radiological Technology, College of Biomedical Technology, Niigata Uiversity, ***Department of Radiology, Niigata University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 4 |
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| Page | 319-326 |
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| Year/Month | 1994/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Regional cerebral blood flow (rCBF) was measured in 13 patients with various cerebral disease by N-isopropyl-p-[123I]iodoamphetamine (IMP) SPECT with the microsphere model (rCBF (CbST) ) , which was compared with 133Xe inhalation SPECT (rCBFXe) . Continuous withdrawal of arterial blood was performed for 5 minutes and SPECT image was obtained from 25 min to 55 min after the tracer injection. The reconstructed counts at 5 min was corrected using entire cerebral counts collected at 5 min, 20 min, and 60 min after the tracer injection. As compared with rCBFXe, rCBF (CbST) was underestimated in high flow areas and overestimated in low flow areas. Regional CBF was also measured using one minute short time SPECT images at 5 min (rCBF (Cb5) ) , 20 min (rCBF (Cb20) ) , and 60 min (rCBF (Cb60) ) after the injection. Regional CBF tended to be underestimated with time from the tracer injection due to the wash-out from brain tissue to blood. In comparison with rCBF (Cb5) , rCBF (CbST) was underestimated in high flow areas and overestimated in low flow areas. This error was considered to be due to the correction of reconstruct counts using entire cerebral counts, because of the kinetic behavior of 123I-IMP was different in each region of the brain. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, Single photon emission computed tomography, rCBF measurement, Microsphere model, Distribution volume. |
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