| Japanese |
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| Title | Diamox負荷99mTc-HMPAO SPECT画像に対する直線化補正 |
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| Subtitle | 技術報告 |
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| Authors | 桑原康雄*, 一矢有一*, 佐々木雅之*, 赤司祐子*, 福村利光*, 吉田毅*, 増田康治* |
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| Organization | *九州大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 3 |
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| Page | 277-282 |
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| Year/Month | 1994/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 Diamox負荷99mTc-HMPAO SPECT画像に対してLassenの直線化補正を試み, PETで得られた結果と比較し, 妥当性を評価した. 対象は脳梗塞9例, モヤモヤ病2例の計11例である. SPECT検査はdouble injection法によった. Diamox負荷画像に対する補正は以下の3つの方法で行った. 1) 小脳の血流量を70ml/min/100 ml (α=1.08) で固定. 2) PETで得られた個々の小脳血流量とそれに対応するαを用いて補正. 3) 安静時画像の小脳と同じカウントの部位の脳血流量が50ml/min/100 ml (α=1.5) となるように補正. 直線化に関しては1) と2) の方法は同等であり, 3) の方法は高血流域でややバラツキが大きく, 1) の方法が簡便でよい方法と考えられた. 3) の方法では, 脳血流量を定量することなしに変化率の算出を試みたが, 平均値ではPETに近い値が得られたものの, 領域ごとの評価では両者は相関せず, 個々の症例に適用するのは困難であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Acetazolamide (Diamox) , 99mTc-HMPAO, Linealization correction, Emission computed tomography. |
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| English |
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| Title | Linealization Correction for Acetazolamide (Diamox) 99mTc-HMPAO SPECT Image - A Comparative Study with PET - |
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| Subtitle | Technical Report |
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| Authors | Yasuo KUWABARA, Yuichi ICHIYA, Masayuki SASAKI, Yuko AKASHI, Tsuyoshi YOSHIDA, Toshimitsu FUKUMURA, Kouji MASUDA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Faculty of Medicine Kyushu University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 3 |
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| Page | 277-282 |
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| Year/Month | 1994/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We attempted to make a linearization correction for the acetazolamide 99mTc-HMPAO SPECT image. These results were compared to those by PET using the H215O-bolus injection method. The subjects consisted of eleven patients with cerebrovascular diseases. The SPECT images were obtained by the double injection method in the resting state and after an administration of acetazolamide (1 g) . Linearization correction was performed according to the Lassen's method. In this study, three different methods were compared, namely fixed Fr and α (70 ml/min/100 ml and 1.08) , individual determination of Fr and α based on PET data, and finally the normalization of the two scan for administered dose, fixed Fr and α (50ml/min/100 ml and 1.5) . The corrected count rate ratios of the 99mTc-HMPAO SPECT images were correlated well with the values of regional cerebral blood flow measured by PET in all methods. Therefore, the first method was considered to be a simple and reliable one. In the last method, the relative change of cerebral blood flow after the administration of acetazolamide was calculated. The means of the percentage increase of cerebral blood flow were in good accord between 99mTc-HMPAO SPECT and PET. However, they showed much discrepancy when individually compared. |
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| Practice | Clinical medicine |
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| Keywords | Acetazolamide (Diamox) , 99mTc-HMPAO, Linealization correction, Emission computed tomography. |
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