| Japanese |
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| Title | 11C-メチオニンを用いたポジトロンCTによる肝機能評価の試み |
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| Subtitle | 短報 |
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| Authors | 榎本和夫*, 松井芳文*, 岡住慎一*, 井奥昇志*, 浅野武秀*, 磯野可一*, 吉川京燦**, 伊藤裕**, 今関恵子***, 吉田弘***, 宇野公一***, 有水昇*** |
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| Authors(kana) | |
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| Organization | *千葉大学医学部第二外科, **附属病院放射線部, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 3 |
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| Page | 271-275 |
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| Year/Month | 1994/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 正常肝7例と閉塞性黄疸肝10例を対象として11C-メチオニンを用いたポジトロンCTを行い, 肝機能評価の可能性を検討した. 針生検によって得た肝組織にトリチウムロイシンを加えて肝蛋白合成率 (HPS) を測定し, differential absorption ratio (DAR) と対比した. 正常肝ではHPSとDARはよく相関した. 黄疸肝症例の2例でHPSが異常高値を示しDARと解離したが, HPSが異常に低い部位はDARも異常に低く, 極端に肝機能が低下した部位はPET画像で見分けられた. 血漿蛋白分画中の11C放射能濃度の上昇率は黄疸肝で高く, 黄疸肝では肝蛋白合成能が亢進しているという従来の報告と一致した. 本法により, 肝機能評価ができる可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 11C-methionine, Positron emission tomography, Liver functional imaging, Evaluation of the liver function. |
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| English |
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| Title | Evaluation of Clinical Usefulness of 11C-Methionine Positron Emission Tomography (11C-MET-PET) as a Tool for Liver Functional Imaging |
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| Subtitle | Short Communications |
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| Authors | Kazuo ENOMOTO*, Yoshifumi MATSUI*, Shinichi OKAZUMI*, Takashi IOKU*, Takehide ASANO*, Kaichi ISONO*, Kyosan YOSHIKAWA**, Hiroshi ITOH**, Keiko IMAZEKI***, Hiroshi YOSHIDA***, Kimiichi UNO***, Noboru ARIMIZU*** |
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| Authors(kana) | |
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| Organization | *Second Department of Surgery, **Division of Radiology, ***Department of Radiology, Chiba University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 3 |
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| Page | 271-275 |
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| Year/Month | 1994/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We studied 11C-MET-PET in 17 clinical cases, 10 patients with obstructive jaundice and 7 normal volunteers, and analyzed its efficacy for the evaluation of hepatic functional reserve in major hepatectomy candidates. Differential absorption ratio (DAR) of 11C was compared to the hepatic protein synthesis rate (HPS) , which is measured as the incorporation rate of 3H-labeled leucine in protein fraction, using needle biopsied liver specimen obtained from each hepatic segment. In the cases of normal liver function, DAR was well correlated with HPS. Also in jaundice cases with two exceptions, low HPS segment was demonstrated as low DAR segment. Consequently, MET-PET images could clearly provide functional liver imaging. After injection of 11C-MET, the increase in rate of radioactivity of 11C in plasma protein fraction was higher in jaundice cases than in normal volunteers, which is in accord with the results of our former study that cholestatic liver has accelerated protein synthesis rate. In summary, since 11C-MET-PET could demonstrate liver functional imaging, it might be a possible tool for liver function assessment in major hepatectomy candidates. |
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| Practice | Clinical medicine |
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| Keywords | 11C-methionine, Positron emission tomography, Liver functional imaging, Evaluation of the liver function. |
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