| Japanese |
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| Title | 健常例における123I-metaiodobenzylguanidine (MIBG) の心筋内分布についての検討 |
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| Subtitle | 原著 |
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| Authors | 土持進作*, 玉木長良*, 白川誠士*, 藤田透*, 米倉義晴*, 小西淳二*, 野原隆司**, 篠山重威**, 西岡研哉*** |
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| Organization | *京都大学医学部放射線核医学科, **第三内科, ***小児科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 3 |
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| Page | 257-264 |
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| Year/Month | 1994/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 123I-MIBGの心筋内分布について年齢による差の有無を検討するため, 心疾患の既往がなく正常と考えられる若年群7例 (<30歳, 平均年齢24.6±3.6) および高齢群8例 (>50歳, 平均年齢60.9±8.4) の2群間で比較した. planar正面像での心臓縦隔比は早期像でおのおの2.39±0.22, 2.42±0.27と有意差は認めなかったが, 後期像では2.91±0.25, 2.67±0.34と若年群で有意 (p<0.05) に高かった. 3時間での心臓からの洗い出し率はおのおの-1.8±22.4%, 12.5±12.7%と有意差はなかった. 下壁前壁比は早期像でおのおの1.15±0.21, 0.96±0.15と有意差はなかったが, 後期像で1.19±0.15, 0.97±0.13と若年群で有意 (P<0.05) に高値を示した. SPECT像でも下壁への集積に年齢差が認められた. MIBGの心筋内分布には年齢による相違があり, その読影には年齢を考慮しなければならないと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-metaiodobenzylguanidine (MIBG) , Normal subjects, Aging, Myocardium. |
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| English |
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| Title | Evaluation of Myocardial Distribution of Iodine-123 Labeled Metaiodobenzylguanidine (123I-MIBG) in Normal Subjects |
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| Subtitle | Original Articles |
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| Authors | Shinsaku TSUCHIMOCHI*, Nagara TAMAKI*, Seishi SHIRAKAWA*, Toru FUJITA*, Yoshiharu YONEKURA*, Junji KONISHI*, Ryuji NOHARA**, Shigetake SASAYAMA**, Kenya NISHIOKA*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, **Third Division, Department of Internal Medicine, ***Department of Pediatrics, Kyoto University Faculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 3 |
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| Page | 257-264 |
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| Year/Month | 1994/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The normal pattern of the myocardial sympathetic innervation was studied in 15 subjects using gamma camera scintigraphy with iodine-123 labeled metaiodobenzylguanidine (123I-MIBG) . Seven younger subjects (mean age 24.6+-3.6) and eight older patients (mean age 60.9+-8.4) with normal cardiac function were studied. Planar imaging was obtained at l5 minute and 3 hours, and SPECT was also performed 3 hours after injection of 111 MBq (3 mCi) of MIBG. The younger subjects showed higher the heart to mediastinum count ratio (2.91+-0.25 vs. 2.67+-0.34;P<0.05) and higher inferior to anterior count ratio (1.l9+-0.15 vs. 0.97+-0.13;P<0.05) on the late scan. The bull's-eye polar map also differences in counts in the mid-inferior (p<0.005) , basal-inferior (p<0.05) and mid-lateral sectors (p<0.01) . But there was no significant difference in MIBG washout rate from myocardium between two groups. These data suggest that there is a difference of the cardiac sympathetic innervation, with older subjects having fewer sympathetic nerve terminals, especially in inferior than younger subjects. We conclude that the age difference in sympathetic nerve function should be considered in the interpretation of MIBG scan. |
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| Practice | Clinical medicine |
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| Keywords | 123I-metaiodobenzylguanidine (MIBG) , Normal subjects, Aging, Myocardium. |
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