| Japanese |
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| Title | Radioimmunotherapyの腫瘍内吸収線量および分布 : 腫瘍サイズ因子との関連 |
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| Subtitle | 原著 |
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| Authors | 藤森研司*,†, 古舘正從* |
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| Organization | *北海道大学医学部核医学講座, †現;札幌医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 3 |
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| Page | 241-248 |
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| Year/Month | 1994/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 Radioimmunotherapyの最適化を支援するために, 腫瘍内吸収線量分布を数学モデルを用いて推定し, 標識核種として67Cu, 90Y, 131I, 186Re, 188Reについて腫瘍サイズによる吸収線量への影響を検討した. 腫瘍サイズ因子の影響のみを検討するため標識抗体の分布は単純化し, 均一な分布と指数関数的な分布について単位時間当たりの吸収線量を求めた. このモデルから:1) 飛程の長いβ線核種では, 腫瘍サイズの増大に伴い吸収線量が増加するが, 腫瘍外への線量分布も多い;2) 飛程の短い核種ではサイズ因子の寄与は少ない. 腫瘍外への線量分布は少なく, 小さい腫瘍において効果的である;3) 標識抗体の分布が不均一な場合, 飛程の長い核種ほど線量分布は均一に近い. 飛程の短い核種では, 線量分布の不均一性が顕著であることが示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Monoclonal antibody, Radioimmunotherapy, Dosimetry, Radionuclides, Tumor size. |
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| English |
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| Title | Dosimetry and Radiation Dose Distribution in Tumors for Radioimmunotherapy : The Effect of Tumor Size |
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| Subtitle | Original Articles |
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| Authors | Kenji FUJIMORI, Masayori FURUDATE |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, Hokkaido University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 3 |
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| Page | 241-248 |
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| Year/Month | 1994/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] For aiding to optimize the efficiency of radioimmunotherapy with β-emitter-labeled monoclonal antibody (MAb) , radiation absorbed dose in a small tumor was calculated using a mathematical model for 67Cu, 90Y, 131I, 186Re, and 188Re. MAb distributions were assumed to be uniform or exponential to investigate the tumor size effect on absorbed dose. The salient results are 1) with longer range β-emitters, radiation absorbed dose is increased with the tumor size increases and the fraction of radiation dose to the outside of the tumor is large;2) with shorter range β-emitters, the tumor size effect on absorbed dose is small. The fraction of radiation dose to the tumor is large and small tumors will be irradiated effectively;3) when MAb distribution is non-uniform, absorbed dose is more homogenous with longer range β-emitters. |
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| Practice | Clinical medicine |
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| Keywords | Monoclonal antibody, Radioimmunotherapy, Dosimetry, Radionuclides, Tumor size. |
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