| Japanese |
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| Title | N-isopropyl-p-[123I]iodoamphetamine (IMP) と回転型ガンマカメラを用いたmicrosphere modelに基づく脳血流測定法の精度の検討 - PaCO2による補正の必要性 - |
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| Subtitle | 原著 |
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| Authors | 小田野行男*, 高橋直也*, 大久保真樹**, 大滝広雄*, 野口栄吉*, 羽田野政義*, 山崎芳裕*, 西原真美子* |
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| Authors(kana) | |
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| Organization | *新潟大学医学部放射線医学教室, **新潟大学医療技術短期大学診療放射線技術学科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 3 |
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| Page | 223-229 |
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| Year/Month | 1994/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」133Xe吸入法SPECTによる脳血流測定法を基準の検査として, 123I-IMPと回転型ガンマカメラを用いたマイクロスフェアー法に基づく脳血流測定法の精度を評価した. 脳血管障害など9例を対象に両検査を同日に施行したが, 両者の平均脳血流の間には相関が見られなかった. その主たる原因は検査時の動脈血炭酸ガス分圧 (PaCO2) の違いにあると推測した. そこで過呼吸試験を負荷しながら123I-IMP SPECTにて脳血流を測定し, 安静呼吸時の脳血流と比較して, 炭酸ガス分圧1mmHgあたりの脳血流の変化率 (1.02ml/100g/min/mmHg PaCO2) を求めて補正を行った. その結果, 両検査法により測定した平均脳血流はきわめてよく相関した. 治療効果判定や負荷試験など, 同一症例において脳血流の変化を比較検討する場合には炭酸ガス分圧で脳血流を補正する必要がある. また133Xe吸入法SPECTは, このような補正をしない限り脳血流測定の基準検査にはならないと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, 133Xe-inhalation, Regional CBF, SPECT, Hyperventilation |
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| English |
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| Title | A Study on Evaluation of CBF Measurement Based on Microsphere Model with N-Isopropyl-p-[123I]Iodoamphetamine (IMP) and SPECT - Its Correction with the Value of PaCO2 - |
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| Subtitle | Original Articles |
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| Authors | Ikuo ODANO*, Naoya TAKAHASHI*, Masaki OHKUBO**, Hiro OHTAKI*, Eikichi NOGUCHI*, Yoshimasa HATANO*, Yoshihiro YAMAZAKI*, Mamiko NISHIHARA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Niigata University School of Medicine, **Department of Radiological Technology, College of Biomedical Technology, Niigata University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 3 |
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| Page | 223-229 |
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| Year/Month | 1994/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To evaluate the regional cerebral blood flow measurementwith N-isopropyl-p[123I]iodoamphetamine (IMP) , we performed 123I-IMP SPECT and 133Xe inhalation method on 9 patients with mild cerebrovascular diseases and so on. A tracer dose of 123I-IMP (111 MBq) was injected i.v. and the data were obtained 15 min later. Regional CBF was measured by the microsphere model and arterial blood sampling method. However, mean cerebral blood flow values was not in agreement with both methods. We supposed the reason of the disagreement was due to the difference of PaCO2 when the studies were performed. Hence, CBF measurement with 123I-IMP was performed on the other patient's population with loading of hyperventilation before the IMP injection. Comparing with the control state with normal breathing, we calculated the rate of change of mean CBF between the state with normal breathing and the state with hyperventilation that was 1.02 ml/100 g/min/mmHg PaCO2. After the correction with the rate, we observed a much significant relation between the mean CBF measured with 123I-IMP SPECT and 133Xe inhalation method. When compared CBF values with loading studies or certain therapies, the correction of CBF with the rate of change of PaCO2 is one of the very important factors to be considered. Moreover, 133Xe inhalation method without the correction of PaCO2 can not be a golden standard method for rCBF measurement. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, 133Xe-inhalation, Regional CBF, SPECT, Hyperventilation |
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