| Japanese |
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| Title | 99mTc-MAG3を用いた有効腎血漿流量の測定 - 2-コンパートメントモデルによる解析 - |
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| Subtitle | 技術報告 |
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| Authors | 河相吉*, 菅豊*, 佐藤寿男*, 田中敬正* |
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| Organization | *関西医科大学附属病院放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 2 |
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| Page | 175-181 |
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| Year/Month | 1994/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 新しく開発された腎動態シンチグラフィ製剤99mTc-mercaptoacetyltriglycine (99mTc-MAG3) を用い, 2-コンパートメントモデル解析に基づいた採血不要な有効腎血漿流量 (ERPF) の算出 (クリアランス法) を試み, 腎・尿路疾患の診断における本剤の有用性を検討した. 99mTc-MAG3と123I-ortho-iodohippurate (123I-OIH) を比較したところ (n=9) , クリアランス法で求めた両薬剤の血中消失速度定数およびERPF, ならびにSchlegel法で算出した両薬剤によるERPFはいずれも良好な相関を示した (それぞれr=0.88, r=0.83およびr=0.85) . また, 99mTc-MAG3を用いてクリアランス法で算出したERPFをSchlegel法と比較したところ (n=11) , 両者は良好な相関を示した (r=0.95) . 99mTc-MAG3は123I-OIHと同様にERPFが測定可能であり, また123I-OIHに比してより良好な血流画像および経時的画像が得られ, 腎・尿路疾患の診断に有用な放射性医薬品と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) , 123I-ortho-iodohippurate (123I-OIH) , Effective renal plasma flow (ERPF) , 2-compartment model analysis, Schlegel's method. |
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| English |
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| Title | The Estimation of Effective Renal Plasma Flow (ERPF) Based on Two Compartment Analysis Using 99mTc-Mercaptoacetyltriglycine (99mTc-MAG3) |
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| Subtitle | Technical Reports |
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| Authors | Sang Kil Ha-KAWA, Yutaka SUGA, Hisao SATOU, Yoshimasa TANAKA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Kansai Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 2 |
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| Page | 175-181 |
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| Year/Month | 1994/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The effective renal plasma flow (ERPF) of patients with renal-urinary disorders were estimated employing 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) and a newly-developed clearance method which needs no blood sampling and is based on two-compartment fitting of the cardiac time-activity curves. In comparison with 123I-ortho-iodohippurate (123I-OIH) (n=9) , the disappearance rate constants and ERPF values estimated by the clearance method and the ERPF values by Schlegel's method showed a good correlation between the two agents (r=0.88, r=0.83 and r=0.85, respectively) . The ERPF values evaluated using 99mTc-MAG3 and the clearance method correlated well with those by Schlegel's method (n=11, r=0.95) . These results suggest that 99mTc-MAG3 shows pharmacokinetics which are similar to those of 123I-OIH and that it might be a useful diagnostic tool for estimating the ERPF in patients with renal disorders. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) , 123I-ortho-iodohippurate (123I-OIH) , Effective renal plasma flow (ERPF) , 2-compartment model analysis, Schlegel's method. |
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