| Japanese |
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| Title | 家兎VX-2腫瘍と炎症性病巣のタリウム集積動態の比較検討 |
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| Subtitle | 原著 |
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| Authors | 菅一能*, 西垣内一哉*, 藤田岳史*, 内迫博路*, 伊東克能*, 久米典彦*, 中西敬*, 宇津見博基**, 山田典将** |
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| Organization | *山口大学医学部放射線科, **附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 2 |
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| Page | 151-161 |
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| Year/Month | 1994/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 家兎下腿に移植した長径が10〜82mmの大きさのVX-2腫瘍30個とテレビン油および自家糞溶液の筋肉内注入により作製した合計27個の炎症巣でタリウムの集積動態の差異を検討した. 静注1分後の早期像および30分後の遅延像で病変部の対側健常組織に対する集積比をそれぞれearly, delayed ratioとし, この間のタリウムの残留程度の指標をretention index = (delayed ratio-early ratio) / (early ratio) ×100%とし算出した. 両病巣ともに大きさにより集積動態が異なり, 長径が40mm以下の小病巣では腫瘍は炎症巣に比較してearly, delayed ratioともに高く, retention indexは低値であった. これより大きい病巣では両者の間で集積比に差異はないがretention indexは腫瘍の方が高値であった. 以上の結果から小病巣では腫瘍の方が炎症巣に比べ高い集積を示し, 大きい病巣では腫瘍の方がタリウムの残留が強いことが示され, 両者の間の集積動態の差異が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thallium-201, VX-2 tumor, Inflammatory lesion, Differential diagnosis. |
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| English |
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| Title | Difference of Thallium-201 Kinetics between VX-2 Tumors and Inflammatory Lesions in Rabbits |
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| Subtitle | Original Articles |
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| Authors | Kazuyoshi SUGA*, Kazuya NISHIGAUCHI*, Takeshi FUJITA*, Hiromichi UCHISAKO*, Katsuyoshi ITO*, Norihiko KUME*, Takashi NAKANISHI*, Hiromoto UTSUMI**, Norimasa YAMADA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Yamaguchi University School of Medicine, **Department of Radiology, Yamaguchi University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 2 |
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| Page | 151-161 |
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| Year/Month | 1994/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To evaluate the difference of thallium-201 chloride (201Tl) kinetics between malignant tumors and inflammatory lesions, 201Tl scintigraphy was performed in the 30 rabbits with variable sized VX-2 tumors;and in the 27 rabbits with variable sized inflammatory lesions induced by turpentine oil and the solution of auto-feces. The degree of 201Tl uptake was expressed as the count ratios of the lesions over the contralateral normal muscle tissue, and the early uptake ratio (1 min after the injection) and the delayed uptake ratio (30 min) were acquired. The retention index derived from these ratios was used to assess the degree of 201Tl washout from the lesions. When dividing both the tumors and inflammatory lesions into the large lesions (more than 40 mm in diameter) and smaller ones, different 201Tl kinetics according to the size of the lesions were demonstrated. In the small lesions, the VX-2 tumors showed higher early and delayed uptake ratios and a faster washout than the inflammatory lesions. In contrast, in the large lesions, both the early and delayed uptake ratios were not significantly different;however, the retention index in the tumors was higher compared to the inflammatory lesions. Thus, our animal study indicates that 201Tl kinetics are different according to the size of the tumor and inflammatory lesions, and that in the small lesions the higher tumor uptake compared to the inflammatory lesions may be available to differentiate. However, in the large sized lesions, assessment of the 201Tl washout from the lesions is necessary for differentiation. |
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| Practice | Clinical medicine |
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| Keywords | Thallium-201, VX-2 tumor, Inflammatory lesion, Differential diagnosis. |
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