Japanese
Title123I-metaiodobenzylguanidine (MIBG) 心筋シンチグラフィにおける定量的評価法の検討 - phantomを用いた心筋摂取率の算出法について -
Subtitle原著
Authors百瀬満*, 小林秀樹*, 柏倉健一*, 金谷信一*, 牧正子*, 細田瑳一**, 日下部きよ子*
Authors(kana)
Organization*東京女子医科大学放射線科, **日本心臓血圧研究所循環器内科
Journal核医学
Volume31
Number2
Page143-149
Year/Month1994/2
Article原著
Publisher日本核医学会
Abstract「要旨」123I-MIBGの心筋への取り込みの定量的評価法を検討するために, 心疾患患者45例に対してfirst pass (FP) 法, およびphantomを用いた方法 (Phantom法) によりMIBGの全投与カウントを測定し, その精度を比較した. また, 心縦隔比 (H/M) と, FPによる全投与カウントから算出される心筋摂取率 (MU-FP) とを比較し, 両指標の関連について検討した. 深さ3.5cmのphantom内に設定されたシリンジの投与カウントは, 体重補正を行うことによりFP法と良好な相関 (r=0.81) を得た. また, FP法とPhantom法から算出される両者の心筋摂取率はr=0.94のきわめて良好な相関を示し, Phantom法がFP法の代用として十分使用可能な結果であった. 一方, H/MはMU-FPと相関は認めたが (P<0.001) , 症例間の変動が大きく, 定量的摂取率の代用として応用するには注意が必要と思われた. Phantom法はMIBGの定量評価を行う上で短時間で測定でき, 正確, かつ簡便な方法であり, 日常治療でルーチンに行うことが可能である.
Practice臨床医学：一般
Keywords123I-metaiodobenzylguanidine (123I-MIBG) , Myocardial uptake, Phantom, First pass.
English
TitleQuantitative Analysis of 123I-Metaiodobenzylguanidine Myocardial Scintigraphy by Myocardial Uptake Using a Phantom
SubtitleOriginal Articles
AuthorsMitsuru MOMOSE*, Hideki KOBAYASHI*, Kenichi KASHIKURA*, Shinichi KANAYA*, Masako MAKI*, Saichi HOSODA**, Kiyoko KUSAKABE*
Authors(kana)
Organization*Department of Radiology, Tokyo Women's Medical College, **The Heart Institute of Japan, Tokyo Women's, Medical College
JournalThe Japanese Journal of nuclear medicine
Volume31
Number2
Page143-149
Year/Month1994/2
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] To evaluate the quantitative analysis of 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy, total injected dose measured by first pass (FP) method (TFP) was compared with that measured by phantom method using an acrylic phantom in 45 patients with cardiac disease. Heart per mediastinum ratio (H/M) was compared to myocardial uptake calculated with TFP. The total injected dose measured using the phantom in which the syringe was set in depth of 3.5 cm (Tpham) was correlated with TFp (r=0.73, p=0.0001) . When Tpham was corrected by body weight (c-Tpham) , c-Tpham showed better correlation with TFP. MU calculated by TFP (MU-FP) was well correlated with MU by c-Tpham (MU-pham) (r=0.94, p=0.001) . These results indicate that phantom method is sufficient to substitute for FP method. Though H/M was correlated with MU-FP (p<0.001) , the interpatient variation was relatively large. Then the analysis by H/M is insufficient to substitute for the myocardial up-take. It is thought to be enough to use the phantom method on daily routine work, since this method is accurate and easy to quantitate the myocardial uptake of MIBG taking a short time.
PracticeClinical medicine
Keywords123I-metaiodobenzylguanidine (123I-MIBG) , Myocardial uptake, Phantom, First pass.

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