| Japanese |
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| Title | 99mTc-MAG3による腎動態イメージング検査の臨床的有用性の検討 - 99mTc-DTPA, 99mTc-DMSA, 131I-OIHとの対比 - |
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| Subtitle | 原著 |
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| Authors | 足立至*, 末吉公三*, 杉岡靖*, 小森剛*, 田渕耕次郎*, 小倉康晴*, 中田和伸*, 難波隆一郎*, 辰吉光*, 松井律夫*, 楢林勇* |
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| Authors(kana) | |
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| Organization | *大阪医科大学放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 2 |
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| Page | 131-142 |
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| Year/Month | 1994/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-MAG3 (Mercaptoacetyltriglycine) は99mTc製剤でありながら主に尿細管から排泄される特徴を持っており腎動態機能検査用として期待されている. 各種腎, 尿路疾患の15症例を対象に99mTc-MAG3を使用し, さらに同一症例で13例に99mTc-DTPA, 5例に99mTc-DMSA, 7例に131I-OIHを施行したところ以下のような結果を得た. 99mTc-MAG3による腎動態機能検査は全例で良好な初期血流画像, 経時画像が得られ, レノグラム曲線の作成も容易であった. 99mTc-MAG3の経時画像は99mTc-DTPAの経時画像よりも良好で99mTc-DMSAと同等の診断能が得られた. 99mTc-MAG3のレノグラム曲線は99mTc-DTPAのそれよりも排泄が早く, ERPFを反映するとされる131I-OIHのレノグラム曲線に比較的類似していた. 以上より99mTc-MAG3は良好な初期血流画像, 経時画像およびレノグラム曲線が得られるものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MAG3, 99mTc-DTPA, Kidney, Renogram. |
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| English |
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| Title | Clinical Evaluation of 99mTc-MAG3 Renal Imaging : Comparison with 99mTc-DTPA, 99mTc-DMSA and 131I-OIH |
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| Subtitle | Original Articles |
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| Authors | Itaru ADACHI, Kozo SUEYOSHI, Yasushi SUGIOKA, Takeshi KOMORI, Yasuharu OGURA, Kojiro TABUCHI, Yasunobu NAKATA, Ryuichiro NAMBA, Yoshimitsu TATSU, Ritsuo MATSUI, Isamu NARABAYASHI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Osaka Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 2 |
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| Page | 131-142 |
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| Year/Month | 1994/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The newly developed 99mTc-labeled renal imaging agent, mercaptoacetyltriglycine (MAG3) , is atubular secreted compound. It is expected the most suitable agent to measure renal function and image urinary tract because of the excellent imaging properties and availability of 99mTc and preferred biological qualities of radiohippurates. We examined 15 patients (8 males, 7 females, mean age 55 years old) with renal and urinary tract disease. After drinking 400 ml of water, 185, 370 0r 555 MBq of 99mTc-MAG3 was injected with the supine position. Dynamic scans were acquired for 20 minutes on a large field of view gamma camera (ZLC-7500 Siemens Medical Inc. ) linked to a computer system (Scintipac-2400 Shimadzu Co. ) in a 64×64 matrix. Regions of interest (ROI) were placed around each kidney. Curves of 12 seconds frame rate were generated from all two ROIs over the 20 minutes study. The time to peak count (Tmax) and time from peak count to a half count (T1/2) were calculated from the curve data. 99mTc-DTPA renal imaging was examined to the same patients with the same method like 99mTc-MAG3. The renogram of 131I-orthoiodohippurate (OIH) was performed with probe method. The excellent quality of the renal image was obtained with 185-555MBq of 99mTc-MAG3 compared with the same dose of 99mTc-DTPA respectively. The diagnostic value of 99mTc-MAG3 renal imaging was as well as 99mTc-DMSA renal imaging. The Tmax of 99mTc-MAG3 renogram was same value of that of both 99mTc-DTPA and 131I-OIH renogram. The T1/2 of 99mTc-MAG3 renogram was significantly lower than that of 99mTc-DTPA renogram. The T1/2 of 99mTc-MAG3 renogram was slightly higher that of 131I-OIH renogram. We conclude that the renal imaging of 99mTc-MAG3 was able to acquire the most excellent image and the proper renogram pattern as same as 131I-OIH renogram. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MAG3, 99mTc-DTPA, Kidney, Renogram. |
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