| Japanese |
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| Title | 99mTc-DTPA-ヒト血清アルブミン (HSA-D) SPECTによる脳腫瘍の血管床および血管透過性の評価と201Tl SPECTとの関連について |
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| Subtitle | 原著 |
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| Authors | 中川原譲二*, 福岡誠二*, 高橋州平*, 高橋正昭**, 佐藤勝保**, 末松克美*, 中村順一* |
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| Authors(kana) | |
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| Organization | *中村記念病院脳神経外科, **放射線部 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 2 |
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| Page | 117-124 |
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| Year/Month | 1994/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」天幕上の脳腫瘍25例【転移性脳腫瘍10例, 悪性星細胞腫 (Gr. 3) 8例, 髄膜腫7例】を対象として, 99mTc-DTPA-ヒト血清アルブミン (99mTc-HSA-D) および201Tl SPECTを同日に施行し前者の臨床的意義について検討した. 99mTc-HSA-D SPECTでは, トレーサ投与10分後にearly像, 5時間後にdelayed像を撮像し, 腫瘍への集積度を示すHSA-D index (腫瘍/皮質領域) を算出し, その経時変化およびTl index (腫瘍/対側大脳) との相関関係について分析した. 各腫瘍型においてHSA-D delayed indexは, early indexよりも有意 (P<0.05) に増加した. 各index間の相関関係は腫瘍型により異なり, 悪性星細胞腫と髄膜腫で, HSA-D early indexとdelayed indexが有意 (おのおのP<0.01, P<0.001) に相関し, 悪性星細胞腫においてdelayed indexとTl indexが有意 (P<0.05) に相関した. HSA-D early indexは腫瘍の血管床, delayed indexはその血管透過性を反映し, Tl indexを補う指標として臨床的に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Brain tumor, Permeability, 99mTc-DTPA-human serum albumin, 201Tl SPECT, Vascularity. |
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| English |
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| Title | Assessment of Vascularity and Permeability in Brain Tumor Using SPECT and 99mTc-DTPA-Human Serum Albumin in Relation to 201Tl SPECT |
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| Subtitle | Original Articles |
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| Authors | Jyoji NAKAGAWARA*, Seiji FUKUOKA*, Shuhei TAKAHASHI*, Masaaki TAKAHASHI**, Katsuyasu SATOH**, Katsumi SUEMATSU*, Jun-ichi NAKAMURA* |
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| Authors(kana) | |
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| Organization | *Department of Neurosurgery, **Department of Radiology, Nakamura Memorial Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 2 |
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| Page | 117-124 |
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| Year/Month | 1994/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Single photon emission computed tomography (SPECT) using technetium-99m-DTPA-human serum albumin (99mTc-HSA-D) and thallium-201 chloride (201Tl) was simultaneously performed on 25 patients with brain tumors;10 with brain metastasis, 8 with astrocytoma (Gr. 3) and 7 with meningioma. The early image was obtained 10 minutes after 99mTc-HSA-D (740 MBq) injection, and the delayed image was taken 5 hours after the injection. HSA-D index, based on the ratio of 99mTc-HSA-D uptake in the tumor versus the cortical area, was calculated on each image, and compared with Tl index (tumor/contralateral cerebrum ratio) . HSA-D delayed index was significantly greater than HSA-D early index in all tumor types (p<0.05 by the Wilcoxon ranked sign test) . Linear correlation between HSA-D early index and HSA-D delayed index was significant in astrocytoma (Gr. 3) (p<0.01) and meningioma (p<0.001) , and a linear correlation between HSA-D delayed index and Tl index was significant in astrocytoma (Gr. 3) (p<0.05) . It is concluded that HSA-D early index and delayed index could reflect tumor vascularity and permeability, respectively, and provide supplementary information for Tl index. |
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| Practice | Clinical medicine |
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| Keywords | Brain tumor, Permeability, 99mTc-DTPA-human serum albumin, 201Tl SPECT, Vascularity. |
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