| Japanese |
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| Title | 腫瘍の診断における塩化タリウム (201Tl) 注射液の有用性 (第1報) - 脳腫瘍における検討 - |
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| Subtitle | 技術報告 |
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| Authors | 遠藤啓吾*, 油井信春**, 鈴木謙三***, 鳥塚莞爾**** |
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| Organization | *群馬大学医学部核医学科, **千葉県がんセンター核医学診療部, ***都立駒込病院放射線科, ****福井医科大学 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 1 |
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| Page | 53-61 |
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| Year/Month | 1994/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳腫瘍が疑われた患者48例を対象に, 脳腫瘍の診断における塩化タリウム (201Tl) 注射液 (以下, 本剤) の臨床的有用性を検討した. 本剤は悪性脳腫瘍に高率に集積し (担当医判定で92.3%) , 良性脳腫瘍に比べ3時間後でより強く残存する傾向がみられた. また, 本剤と18F-FDGの病巣/正常部比 (L/N比) が高い相関を示した (r=0.90) ことから, 脳腫瘍の悪性度の診断に有用であると考えられた. 悪性腫瘍の残存・再発群および壊死群におけるL/N比はそれぞれ, 3.33±0.81および1.73±0.81と前者で高く, また, L/N比≧2.5を腫瘍残存と診断した場合の有徴正診率は83.3%, L/N比<2.5を壊死と診断した場合の有徴正診率は100%であり, 放射線壊死と残存・再発群との鑑別に有用であると考えられた. 本剤は安全性に問題なく, 脳腫瘍の悪性度の評価や再発・壊死病巣の鑑別などの質的診断に有用であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thallium-201, Brain tumor, Radiation necrosis, 18F-FDG. |
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| English |
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| Title | Clinical Usefulness of Thallium-201 Chloride in the Diagnosis of Tumors (I) - Evaluation in Brain Tumors - |
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| Subtitle | Technical Reports |
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| Authors | Keigo ENDO*, Nobuharu YUI**, Kenzo SUZUKI***, Kanji TORIZUKA**** |
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| Organization | *Department of Nuclear Medicine, Gunma University School of Medicine, **Division of Nuclear Medicine, Chiba Cancer Center, ***Department of Radiology, Tokyo Metropolitan Komagome Hospital, ****Fukui Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 1 |
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| Page | 53-61 |
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| Year/Month | 1994/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Forty-eight patients with suspected brain tumor were studied to evaluate the clinical efficacy of Thallium-201 (201Tl) SPECT. 201Tl scintigrams showed abnormal accumulation in 24/26 (92.3%) and 9/14 (64.3%) of patients with malignant and benign tumors, respectively. 201Tl tended to be retained more prominently in malignant brain tumors than in benign ones. The lesion-to-normal ratios (L/N ratios) of 201Tl demonstrated significant correlation with those of 18F-FDG (n=5, patients with recurrent tumors than those with necrotic lesions (3.33+-0.81 and 1.73+-0.81, respectively, p=0.0123) . The positive predictive value of L/N ratios>=2.5 for diagnosing as recurrence and L/N ratios<2.5 as necrosis were 83.3% and 100%, respectively. These results suggest that 201Tl scintigraphy may be useful to determine the malignancy of brain tumors and to differentiate recurrence from necrosis after therapeutic procedures. |
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| Practice | Clinical medicine |
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| Keywords | Thallium-201, Brain tumor, Radiation necrosis, 18F-FDG. |
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