| Japanese |
|---|
| Title | 99mTc-HM-PAOによる経直腸門脈シンチグラフィの実験的研究 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 久保田勇人*, 篠塚明*, 武中泰樹*, 玉城聡** |
|---|
| Authors(kana) | |
|---|
| Organization | *昭和大学医学部放射線医学教室, **沖縄県立北部病院放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 31 |
|---|
| Number | 1 |
|---|
| Page | 27-36 |
|---|
| Year/Month | 1994/1 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」最近123I-IMPによる経直腸門脈シンチグラフィの有用性が認められているが, われわれは同じ脳血流シンチグラフィ製剤である99mTc-HM-PAOでも経直腸門脈シンチグラフィが可能であることを見いだした. そこでその有用性を検討するために家兎を用いて実験を行った. 肝外門脈シャントモデルを作製し, 99mTc-HM-PAOと123I-IMPによる門脈シンチグラフィから求めたシャント指数と, 開腹下での下腸間膜静脈への99mTc-MAA注入により求めたシャント率との比較検討を行った. おのおのの相関係数の最高値は99mTc-HM-PAOが0.90, 123I-IMPが0.80であった. 99mTc-HM-PAOの方が高く, また1〜15分の各時間とも0.80以上あり安定していた. 99mTc-HM-PAOは大量投与が可能であり, 直腸からの吸収が良好で門脈系が明瞭に描出された. 正常群では肝extraction fractionは94.4%で, 肝からの排泄率は低く, 経直腸門脈シンチグラフィ製剤として有用であることが明らかになった. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Per-rectal portal scintigraphy, Portosystemic shunt, 99mTc-HM-PAO, 123I-IMP, 99mTc-MAA. |
|---|
| English |
|---|
| Title | Experimental Study of Per-rectal Portal Scintigraphy Using 99mTc-HM-PAO |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Hayato KUBOTA*, Akira SHINOTSUKA*, Hiroki TAKENAKA*, Satoshi TAMAKI** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, Showa University School of Medicine, **Department of Radiology, Okinawa Prefectural North Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 31 |
|---|
| Number | 1 |
|---|
| Page | 27-36 |
|---|
| Year/Month | 1994/1 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Usefulness of per-rectal portal scintigraphy by 123I-IMP has already been admitted. We assessed whether 99mTc-HM-PAO, another agent used for cerebral blood flow scintigraphy, could be utilized for scintigraphic evaluation of the portal system. Animal experiments were carried out to evaluate the usefulness of the examination. Shunt indices obtained from per-rectal portal scintigraphy by 123I-IMP and 99mTc-HM-PAO in shunt models and shunt rate obtained by direct injection of 99mTc-MAA into the inferior mesenteric vein under laparotomy were compared. Correlation coefficient of each agent with 99mTc-MAA was 0.90 for 99mTc-HM-PAO and 0.80 for 123I-IMP. It was also noted that as larger quantity of the tracer could be administrated in 99mTc-HM-PAO than in 123I-IMP, absorption from rectum was optimum and liver extraction fraction was 94.4%. Therefore, we concluded that 99mTc-HM-PAO was useful for per-rectal portal scintigraphy. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Per-rectal portal scintigraphy, Portosystemic shunt, 99mTc-HM-PAO, 123I-IMP, 99mTc-MAA. |
|---|