| Japanese |
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| Title | 虚血性心疾患における99mTc-tetrofosminを用いた心筋灌流および左室壁運動の同時評価 |
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| Subtitle | 原著 |
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| Authors | 外山卓二*, 西村恒彦***, 植原敏勇***, 下永田剛*, 林田孝平*, 石田良雄*, 野々木宏**, 土師一夫** |
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| Organization | *国立循環器病センター放射線診療部, **心臓内科, ***大阪大学医学部トレーサ解析学 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 1 |
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| Page | 1-9 |
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| Year/Month | 1994/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 運動負荷および安静時に99mTc-tetrofosmin心筋シンチグラフィおよびファーストパス心プールシンチグラフィを同時に施行し冠動脈病変の検出能について検討した. 対象は冠動脈疾患24例で, 一枝病変9例 (SVD群) , 多枝病変15例 (MVD群) である. 冠動脈病変の検出能では感度はPlanar像でSVD群78%, MVD群73%, SPECT像でそれぞれ78%, 87%であった. 左室駆出率 (LVEF) および左室局所駆出率 (rEF) を併用するとPlanar像, SPECT像ともSVD群で89%, MVD群で100%と上昇した. 罹患冠動脈診断精度はLAD診断が79%, LCX診断が88%, RCA診断が83%と良好であった. 局所心筋灌流とrEFの検討では, 虚血領域のrEFは両群とも低下し, 特にMVD群でより低値を示した. 相対的正常灌流域のrEFはSVD群で有意な変化を示さなかったのに対しMVD群で低下した. 99mTc-tetrofosminは心筋灌流および心機能の同時評価が可能でありかつ一枝, 多枝病変の判別に有用であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-tetrofosmin, Coronary artery disease, Myocardial perfusion, First-pass radionuclide angiography. |
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| English |
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| Title | Simultaneous Assessment of Exercise-Induced Abnormalities in Myocardial Perfusion and Regional Wall Motion by Using 99mTc-Tetrofosmin |
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| Subtitle | Original Articles |
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| Authors | Takuji TOYAMA*, Tsunehiko NISHIMURA***, Toshiisa UEHARA***, Tsuyoshi SHIMONAGATA*, Kohei HAYASHIDA*, Yoshio ISHIDA*, Hiroshi NONOGI**, Kazuo HAZE** |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, **Division of Cardiology, National Cardiovascular Center, ***Department of Tracer Kinetics, Osaka University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 1 |
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| Page | 1-9 |
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| Year/Month | 1994/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To clarify the usefulness of the combined assessment of exercise (EX)-induced abnormalities in myocardial perfusion and regional wall motion for detecting coronary artery disease (CAD) . we carried out first-pass radionuclide angiography and myocardial perfusion imaging during EX and at rest by 99mTc-tetrofosmin. Twenty-four patients with angiographically proven CAD, 9 (Gp A) with single and 15 (Gp B) with multivessel disease, were studied. The sensitivity for the detection of CAD was 78% of Gp A, 73% of Gp B in planar image and 78%, 87% in SPECT image, respectively. When left ventricular ejection fraction and regional ejection fraction (rEF) were combined with the result of myocardial perfusion, sensitivity increased up to 89% of Gp A, 100% of Gp B. Diagnostic accuracy of LAD, LCX and RCA was 79%, 88% and 83%, respectively. Regional EF in ischemic areas decreased during EX in both Gps, particularly in Gp B. Regional EF in relatively normal perfusion areas did not significantly change in Gp A, but decreased in Gp B. These results suggest that 99mTc-tetrofosmin contributes to the improvement of sensitivity for CAD by combined assessment of EX-induced wall motion and myocardial perfusion abnormalities. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-tetrofosmin, Coronary artery disease, Myocardial perfusion, First-pass radionuclide angiography. |
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