| Japanese |
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| Title | 線形グラフプロット法による局所脳血流量の定量解析法の開発 : 123I-IMPダイナミックSPECTへの応用 |
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| Subtitle | 《原著》 |
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| Authors | 横井孝司*, 飯田秀博**, 伊藤浩**,***, 菅野巖** |
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| Organization | *島津製作所医用技術部, **秋田県立脳血管研究センター放射線医学研究部, ***東北大学加齢医学研究所 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 12 |
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| Page | 1451-1457 |
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| Year/Month | 1993/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 われわれは, 局所脳血流量(rCBF)の定量化のために, 2コンパートメントモデルに基づくグラフプロット法による新しい解析法を開発した. X軸にスキャン時間を, Y軸に入力関数積分値と脳組織放射能濃度の比をとれば直線関係が得られ, Y軸切片がrCBFの逆数を表すことを導いた. 5例の正常人に対して123I-IMPダイナミックSPECT測定を行い, 本法を応用して解析した. 得られたrCBFの灰白質での平均値は, 42.1±6.8ml/100g/minであった. また, 本法を用いてrCBF画像の作成を行った. 本法は原理的にはダイナミック測定が必要ではなく, 2回のSPECT測定でrCBFが求められる利点を持っている. 結論として, 本法は高速にrCBFを求める新しい方法として有用であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, rCBF, SPECT, Graphical method. |
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| English |
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| Title | A New Method for Quantitative Measurement of rCBF Using Graphic Plot Analysis : Application to 123I-IMP Dynamic Study |
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| Subtitle | Original Articles |
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| Authors | Takashi YOKOI*, Hidehiro IIDA**, Hiroshi ITOH**,***, Iwao KANNO*** |
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| Authors(kana) | |
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| Organization | *Department of Research for Medical Systems, Shimadzu Corporation, **Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, ***Department of Radiology and Nuclear Medicine, Research Institute for Cancer and Tuberculosis, Tohoku University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 12 |
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| Page | 1451-1457 |
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| Year/Month | 1993/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To estimate regional cerebral blood flow (rCBF) using the dynamic data, a new graphic plot analysis is proposed. By assuming a two-compartment model for the tracer kinetics, we derived the linear relationship as Y(t)=1/K1+θt, where Y(t) is the ratio of time-integrated blood activity to brain tissue activity, t is the scan time, and θ is a proportional constant. A plot of Y(t) against the scan time t yields a straight line and the y-intercept of the line represents the value of inverse rCBF K1. This method was applied to five normal subjects with N-isopropyl-p(123I)iodoamphetamine. The mean value of K1 in the gray matter was 42.1+-6.8 ml/100g/min. We also produced the rCBF images within a few seconds using the present method. The present graphical method gives a reliable and rapid estimation of rCBF. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, rCBF, SPECT, Graphical method. |
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