Japanese
Title1型コラーゲンのピリヂノリン架橋C端蛋白 (1CTP) の血中濃度の測定 - 測定キットの基礎的検討と諸種疾患における臨床的検討 -
Subtitle《技術報告》
Authors山本逸雄*, 高田政彦*, 游逸明*, 大中恭夫*, 木上裕輔*, 山本裕子*, 浜津尚就**, 森田陸司*
Authors(kana)
Organization*滋賀医科大学放射線科, **滋賀医科大学放射線部
Journal核医学
Volume30
Number11
Page1411-1417
Year/Month1993/11
Article報告
Publisher日本核医学会
Abstract「要旨」 1型コラーゲンの代謝産物であるピリヂノリン含有1型コラーゲンC端ペプチド(1CTP)の血中RIAキットの基礎的, 臨床的検討を行った. 本アッセイは, 再現性良好で短時間に測定可能で従来の尿中ピリヂノリン測定系に比しきわめて簡便である. 健常人の検討では, 24歳以下の若年者と45歳以上の高齢者において高値を示す傾向が認められた. 骨吸収をきたす疾患, 特に転移性骨腫瘍の早期に異常高値を示す例が多く, 骨転移の評価に関し他の骨代謝マーカーより有用であると考えられた. また, 副甲状腺機能亢進症や甲状腺機能亢進症, 胃切症例, 悪性腫瘍に伴う高カルシウム血症の代謝性骨疾患をはじめ骨髄腫, 関節リウマチ, 変形性関節疾患などの骨吸収状態に関連して高値を示す症例が認められた. このように1型コラーゲンの代謝を鋭敏に反映するアッセイの登場は, 骨代謝の評価においてきわめて有意義であると考えられ, 今後の広範な検討が期待される.
Practice臨床医学：一般
KeywordsCollagen, Bone resorption, Pyridinoline, Metabolic bone disease, Bone metastasis.
English
TitleRadioimmunoassay for the Pyridinoline Cross-Linked Carboxy-Terminal Telopeptide of Type 1 Collagen (1CTP) - Some Basic Aspects of the RIA Kit and Clinical Evaluation in Various Bone Diseases -
Subtitle
AuthorsItsuo YAMAMOTO, Masahiko TAKADA, Itsuaki YUU, Yasuo OHNAKA, Yuusuke KIGAMI, Yuuko YAMAMOTO, Hisatoshi HAMAZU, Rikushi MORITA
Authors(kana)
OrganizationDepartment of Radiology and Radioisotope Division, Shiga University of Medical Science
JournalThe Japanese Journal of nuclear medicine
Volume30
Number11
Page1411-1417
Year/Month1993/11
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] A radioimmunoassay for circulating levels of the pyridinoline cross-linked carboxy-terminal telopeptide of type 1 collagen (1CTP) was developed and can be available as a kit on a commercial base. Using the kits, we evaluated basically and clinically the assay. The assayed values were reproducible and the assay can detect as low as 0.5 ng/ml of 1CTP. In healthy volunteers, circulating level was high under age 24 and over age 46. In patients with bone metastasis, serum levels elevated even in its early stage and correlated well with clinical status. In other bone diseases, such as primary hyperparathyroidism, hyperthyroidism, post-gastrectomy, hypercalcemia of malignancy and myeloma, serum levels elevated according to their clinical conditions. In patients with chronic renal failure, serum levels were high, suggesting decrease of renal clearance of 1CTP. The circulating 1CTP levels seemed to reflect well clinical bone destructive status. A high correlation between serum 1CTP level and urinary pyridinoline (r=0.884) was shown, whereas essentially no correlation was observed between bone formation markers such as osteocalcin and alkaline phosphatase. Thus, the measurement of circulating 1CTP seems to be a simple and sensitive method to monitor bone destruction.
PracticeClinical medicine
KeywordsCollagen, Bone resorption, Pyridinoline, Metabolic bone disease, Bone metastasis.

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