| Japanese |
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| Title | 大腸癌に対する111In-トランスフェリンシンチグラフィの臨床的有用性の検討 |
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| Subtitle | 《原著》 |
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| Authors | 平野盛久*, 成木行彦*, 瓜田純久*, 中谷尚登*, 野口雅裕**, 高野政明***, 丸山雄三***, 大塚幸雄* |
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| Authors(kana) | |
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| Organization | *東邦大学医学部第一内科, **東邦大学佐倉病院放射線科, ***東邦大学大森病院中央放射線部 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 11 |
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| Page | 1369-1377 |
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| Year/Month | 1993/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 大腸癌患者26症例28病変に対し, 111In-トランスフェリンを用いてシンチグラフィを試み, その臨床的有用性を検討した. 28病変中21病変(75%)と高率に描出された. 腫瘍部位での検討では, 上行結腸, 横行結腸で描出率が高い傾向にあったが, Borrmannによる形態分類, 組織型および肉眼的壁深達度では明らかな傾向は認めなかった. しかし, 腫瘍最大径が大きく深達度が進展している例でシンチグラム陽性率が高くなる傾向を示した. 切除標本10例のシンチグラフィでは全例陽性の所見を示した. 腫瘍部分の放射能は, 非腫瘍部分に比較し4.41±2.96倍と高値であった. 抗トランスフェリンレセプター抗体による免疫組織染色では, 癌組織に一致し強く染色された. 以上より, 111In-トランスフェリンは大腸癌組織に集積することが明らかであり, シンチグラフィとして臨床的に有用であると思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 111In transferrin scintigraphy, Colorectal cancer, Tranferrin receptor. |
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| English |
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| Title | Clinical Usefulness of 111In Transferrin Scintigraphy in Colorectal Cancer |
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| Subtitle | Original Articles |
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| Authors | Morihisa HIRANO*, Yukihiko NARUKI*, Yosihisa URITA*, Naoto NAKATANI*, Masahiro NOGUCHI**, Masaaki TAKANO***, Yuuzou MARUYAMA***, Sachio OTSUKA* |
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| Authors(kana) | |
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| Organization | *First Department of Internal Medicine, **Department of Radiology, Sakura Hospital, ***Radiological Center, School of Medicine, Toho University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 11 |
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| Page | 1369-1377 |
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| Year/Month | 1993/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] As assessment was made regarding the clinical value of 111In transferrin in scintigraphy on 28 lesions in 26 cases of colorectal cancer. The positive rate of colorectal cancer was high : 21 lesions out of the 28 (75%) were found to be positive. As for the location of cancer, there was a tendency for the positive rate to be high in the ascending and transverse colon. There was no obvious trend regarding Borrmann's classification, histological type, or macroscopic depth of invasion. There was a trend for cases in which the maximum diameter of the tumor was large and depth of invasion was in progress to be positive. Ten cases in which a specimen was resected were all shown to be positive by scintigraphy. Radioactivity in the tumorous regions was 4.41+-2.96 times that of the non-tumorous regions. Moreover, tumorous tissue was strongly stained by the immuno-histological staining with anti-Tf-receptor antibody. From the above findings, it was considered that 111In transferrin is clinically useful in scintigraphy, since it is evident that it accumulates in the tissue of colorectal cancer. |
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| Practice | Clinical medicine |
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| Keywords | 111In transferrin scintigraphy, Colorectal cancer, Tranferrin receptor. |
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