| Japanese |
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| Title | 痴呆およびADL低下例における局所脳血流量 - 123I-IMP SPECTによる検討 - |
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| Subtitle | 《原著》 |
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| Authors | 岩宮孝司*, 太田吉雄*,** |
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| Organization | *鳥取大学医学部放射線医学教室, **主任 : 教授 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 11 |
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| Page | 1341-1351 |
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| Year/Month | 1993/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 123I-IMPを用いた持続動脈採血法による局所脳血流量測定を111例(脳梗塞53例, パーキンソン病34例, アルツハイマー型老年痴呆(SDAT)7例, 脊髄小脳変性症5例, TIA 4例, その他8例)に施行し, 痴呆の有無および日常生活動作(ADL)と局所脳血流量との関係について検討を行った. 痴呆群での全脳平均脳血流量は有意に低下しており(p<0.01), 両側前頭葉・頭頂葉・基底核, 右側頭葉, 左小脳領域の有意な血流低下を認めた. また, 痴呆群の中でもSDAT症例(7例)では, 非痴呆群に比し両側前頭葉, 右頭頂葉, 両側側頭葉, 両側後頭葉, 左基底核において有意なrCBFの低下を認めた. 疾患別では, 脳梗塞の痴呆合併例では両側基底核に有意な血流低下を認めたが, パーキンソン病の痴呆合併例では, 局所的に有意な血流低下は認めなかった. ADL低下(要介助)群では, ADL良好(自立)群に比し全脳平均脳血流量は有意に低下しており(p<0.01), 左後頭葉以外の全領域で有意なrCBFの血流低下が認められ, 広範な脳実質障害が示唆されたが, 特に両側前頭葉・基底核に高度の血流低下を認めた. 脳梗塞ADL低下例では, 両側基底核に有意な血流低下を認め, 皮質脊髄路の障害が主体と考えられたが, パーキンソン病のADL低下例では局所的な血流低下は明らかでなく, 局所脳血流測定で評価し得ない代謝障害の存在も考えられた. 123I-IMPを用いた局所脳血流量の定量的評価は, 痴呆およびADL低下例における病態評価ならびに経過観察に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, Regional cerebral blood flow, Microsphere model, Dementia, ADL. |
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| English |
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| Title | Quantitative Regional Cerebral Blood Flow Study with 123I-IMP in Patients with Dementia and in Patients with Poor Activities of Daily Living |
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| Subtitle | Original Articles |
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| Authors | Takashi IWAMIYA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Tottori University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 11 |
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| Page | 1341-1351 |
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| Year/Month | 1993/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] N-isopropyl-p[123I]iodoamphetamine (123I-IMP) SPECT and quantitative regional cerebral blood flow (rCBF) studies were performed in 111 patients with cerebral disorders. Continuous arterial blood sampling method based on the microsphere model was used as a quantitative rCBF measurement. We evaluated rCBF in patients with dementia and also in patients with poor activities of daily living (ADL). Patients with dementia showed significant reduction of mean CBF in contrast to patients without dementia. Significant decrease of rCBF in the bilateral frontal cortex, parietal cortex and basal ganglia and the right temporal cortex were found in demented patients. Although patients with vascular dementia showed decreased rCBF in bilateral basal ganglia, demented patients with Parkinson's disease showed no significant reduction of rCBF in any regions. Patients with poor ADL showed decreased rCBF in all brain regions. And particularly frontal and basal ganglionic defects were most pronounced. Patients with poor ADL resulted from cerebral infarction showed significant decrease of rCBF in bilateral basal ganglia. However, there was no significant correlation in Parkinson's disease between ADL and rCBF. The rCBF measurement with 123I-IMP is useful for clinical evaluation of demented patients and patients with poor ADL. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, Regional cerebral blood flow, Microsphere model, Dementia, ADL. |
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