| Japanese |
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| Title | 99mTc-galactosyl serum albuminの血中消失補正肝摂取率LHL/HHの肝機能指標としての有用性 |
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| Subtitle | 《原著》 |
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| Authors | 河相吉*, 菅豊*, 池田耕士*, 永田憲司*, 村田貴史*, 田中敬正* |
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| Organization | *関西医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 11 |
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| Page | 1333-1339 |
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| Year/Month | 1993/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 185MBq/3mgの99mTc-galactosyl serum albumin(GSA)肝シンチによる肝機能評価の指標として血中消失補正肝摂取率LHL/HHを算定した. 99mTc-GSAの3つの比率指標である肝摂取率LHL15, 血中消失率HH15, 両者の商LHL/HHを血中停滞率(%ID15), CTCスコアによる肝疾患重症度と比較検討した. 対象は78例の慢性肝疾患患者である. LHL15は%ID15の低値域では平坦相を形成するために, 両者は直線相関を示さなかった. これに対して, LHL/HHは%ID15の変動と全区間において良好な直線近似を示した. 重症度別の比較では, 機能正常群と軽症群間ではLHL/HH(p<0.001)はLHL15(p=0.005)よりも強い有意差を示し, また軽症群と中等症群間ではHH15(p=0.07)が有意でなかったのに対し, LHL/HH(P=0.032)は有意差を示した. LHL/HHは特別な解析手順を必要とせずに簡便に算出でき, 血中消失率と肝摂取率の両者を一元化した動態指標とみなすことができ, 99mTc-GSAを用いた肝機能評価を行う上で有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Liver scintigraphy, Asialoglycoprotein, Liver function, Radiopharmaceuticals. |
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| English |
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| Title | Usefulness of Blood Disappearance Corrected Hepatic Uptake Ratio (LHL/HH) as a Hepatic Functional Index Using 99mTc-Galactosyl Serum Albumin |
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| Subtitle | Original Articles |
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| Authors | Sang Kil Ha-KAWA, Yutaka SUGA, Koshi IKEDA, Kenji NAGATA, Takashi MURATA, Yoshimasa TANAKA |
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| Organization | Department of Radiology, Kansai Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 11 |
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| Page | 1333-1339 |
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| Year/Month | 1993/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The authors introduced blood disappearance corrected hepatic uptake ratio (LHL/HH) as an index of hepatic function using 185 MBq/3 mg of 99mTc-galactosyl serum albumin (GSA). Three ratio parameters, the hepatic uptake ratio (LHL15), blood disappearance ratio (HH15), and LHL15 divided by HH15 (LHL/HH) were evaluated with percent injected dose of 99mTc-GSA in blood at 15 min after injection (%ID15) and hepatic functional severity graded by Child-Turcotte criteria score. Seventy eight patients with chronic liver disease were studied. There was a poor linear correlation between the LHL15 and %ID15, because the LHL15 formed a plateau phase in the lower-value range for %ID15. In contrast, LHL/HH showed an excellent linear correlation with %ID15 in its whole range. In the comparison with the clinical functional severity, LHL/HH gave a more highly significant difference (p<0.001) than LHL15 (p=0.005) between the normal and mild dysfunction groups and gave a significant difference (p=0.032) between the mild and moderate groups, in which HH15 showed no meaningful difference (p=0.07). This index is obtained with no difficult procedures and can be regarded as a unified parameter for hepatic uptake and blood disappearance. It is hoped that LHL/HH will prove useful in the diagnosis of hepatic functional severity using 99mTc-GSA. |
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| Practice | Clinical medicine |
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| Keywords | Liver scintigraphy, Asialoglycoprotein, Liver function, Radiopharmaceuticals. |
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