| Japanese |
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| Title | 99mTc-HM PAO肺集積における喫煙の影響 |
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| Subtitle | 原著 |
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| Authors | 高橋恒男*, 小原東也*, 小野恵*, 菊池みかる*, 柳澤融* |
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| Organization | *岩手医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 10 |
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| Page | 1231-1234 |
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| Year/Month | 1993/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」健康な非喫煙男性4名 (29.3±7.3歳) と喫煙男性10名 (39.5±11歳, Brinkmann指数544±270.8) を対象とし, 99mTc-HM PAO 740 MBq急速静注後の肺への初期分布および洗い出し過程を, 1フレーム/分30分間データ収集を行い, 各ピクセルごとの時間放射能曲線をC (t) =A exp-ktで表す1コンパートメントモデルで解析, また30分後の肺/肝摂取比 (Lu/Li index) をもとめ対比検討した. その結果, 喫煙例では非喫煙例に比し有意にkは小, Lu/Li indexは高値であった. またBrinkmann指数とkは有意な負の相関, Lu/Li indexとは有意な正の相関をみた. したがって, 喫煙は99mTc-HM PAOの肺集積に影響を与える重要な因子といえる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-HM PAO, Diffuse pulmonary uptake, Cigarette smoking. |
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| English |
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| Title | Effect of Cigarette Smoking on Diffuse Pulmonary Uptake of 99mTc-HM PAO |
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| Subtitle | Original Articles |
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| Authors | Tsuneo TAKAHASHI, Toya OBARA, Megumi ONO, Mikaru KIKUCHI, Toru YANAGISAWA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Iwate Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 10 |
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| Page | 1231-1234 |
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| Year/Month | 1993/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To investigate the clinical significance of pulmonary uptake of 99mTc-HM PAO, we studied the effect of cigarette smoking on pulmonary uptake of 99mTc-HM PAO. This study included 14 volunteers: 4 non-smokers and 10 smokers (Brinkmann indexes 544+-270.8) . Following injection of 99mTc-HM PAO into the antecubital vein, time-activity curve was obtained with the regional activity of one frame/min. for 30 minutes and 64×64 matrices. Characteristics of pulmonary clearance curve, described as C (t) =A exp-kt, and lung/liver uptake ratio (Lu/Li index) at 30 min, after injection were determined, and groups of non-smokers and smokers were compared. In smokers, 99mTc-HM PAO clearance was delayed and k was smaller significantly. Lu/Li index was also higher in smokers. Brinkmann index correlated both with k (r=-0.815, p<0.01) and Lu/Li index (r=0.911, p<0.01) . In conclusion, the delayed clearance and retention of 99mTc-HM PAO in the lung may indicate metabolic disorders of the lung due to cigarette smoking. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-HM PAO, Diffuse pulmonary uptake, Cigarette smoking. |
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