| Japanese |
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| Title | 各種膵疾患における血中膵ホスホリパーゼA2測定の有用性について |
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| Subtitle | 技術報告 |
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| Authors | 宮本佳一*, 川又由一*, 横井川英男*, 山本英嗣*, 片岡慶正**, 加嶋敬** |
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| Organization | *株式会社ファルコイムノシステムズ, **京都府立医科大学第三内科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 9 |
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| Page | 1103-1110 |
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| Year/Month | 1993/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」血中膵ホスホリパーゼA2 (以下膵PLA2) 測定のRIAキットの基礎的検討および臨床的有用性の検討を行った. 本キットの基礎的検討の結果, その性能はほぼ満足できる成績であった. また臨床的有用性の検討において, 主に膵疾患患者を対象に血中膵PLA2測定を実施した. 急性膵炎 (n=7) 症例では血中膵PLA2値はすべて異常高値であり, 慢性膵炎 (n=93) および膵癌 (n=37) 症例では異常高値から異常低値まで幅広い分布を示した. さらに他の膵マーカーであるアミラーゼ, エラスターゼ1, トリプシンおよびPSTIと比較検討した結果, 血中膵PLA2測定は膵疾患に対する特異性が高く, 最もすぐれた成績であった. 血中膵PLA2の異常高値群は, 膵疾患の膵の炎症状態, 異常低値群は膵外分泌の機能低下を反映するものと考えられる. したがって血中膵PLA2測定は, 膵臓の病態変化を知る有力な検査として期待できる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Pancreatic phospholipase A2, Pancreatic diseases. |
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| English |
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| Title | Usefulness of Serum Pancreatic Phospholipase A2 Determination in Patients with Various Pancreatic Diseases |
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| Subtitle | |
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| Authors | Yoshikazu MIYAMOTO*, Yoshikazu KAWAMATA*, Hideo YOKOIGAWA*, Hidetsugu YAMAMOTO*, Keisyo KATAOKA**, Kei KASHIMA** |
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| Organization | *FALCO Immuno Systems, **Third Department of Internal Medicine, Kyoto Prefectural University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 9 |
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| Page | 1103-1110 |
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| Year/Month | 1993/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A radioimmunoassay kit (SHIONORIA(R) P-PLA2) to measure human serum pancreatic phospholipase A2 (P-PLA2) concentrations was evaluated for their basic properties and clinical usefulness. The performance of the kit was found to be quite satisfactory. To test its clinical usefulness, specimens mainly from patients with pancreatic diseases were obtained and examined for serum P-PLA2 levels. All serum specimens from patients with acute pancreatitis (n=7) were found to have elevated levels of serum P-PLA2. In patients with chronic pancreatitis (n=93) and pancreatic cancer (n=37) , serum P-PLA2 levels showed a wide range of distribution, from abnormally elevated values to abnormally low values. We compared these data with those of other pancreatic markers such as:amylase, elastase 1, trypsin, and PSTI. Among these, P-PLA2 was highly specific to pancreatic disease and best represented the state of pancreatic disorders. Abnormally elevated levels of serum P-PLA2 concentrations seem to reflect the inflammation of pancreas, while abnormally low levels indicate the hypofunction of pancreatic exocrine glands. These results suggest that the measurement of serum P-PLA2 concentrations is a useful diagnostic test for pancreatic disorders. |
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| Practice | Clinical medicine |
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| Keywords | Pancreatic phospholipase A2, Pancreatic diseases. |
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