| Japanese |
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| Title | 99mTc-HMPAO SPECTによるCrossed cerebellar diaschisisにおけるacetazolamideに対する脳血管反応性の検討 |
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| Subtitle | 原著 |
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| Authors | 寺田一志*, 五味達哉**, 佐々木郷子**, 村上省吾**, 佐藤設**, 長基雅司**, 桑島章**, 平松慶博**, 岩渕聡***, 鮫島寛次***, 吉井信夫*** |
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| Authors(kana) | |
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| Organization | *東京女子医科大学脳神経センター神経放射線科, **東邦大学放射線医学第二教室, ***脳神経外科学第二教室 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 9 |
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| Page | 1075-1080 |
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| Year/Month | 1993/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」acetazolamide (DIAMOXR) を投与する前後の連続した2回の99mTc-HMPAO SPECTを用いて, crossed cerebellar diaschisis (CCD) を示す領域における血管反応性を検討した. DIAMOX負荷前後の脳血流SPECTを施行し, 左右の小脳半球に関心領域をとり, 半定量的検討を加え, 正常者と比較した. その結果baseline像の半定量的評価でCCDありとなった14例のうち11例で, 小脳半球の血流の左右差にDIAMOX負荷によると考えられる有意な減少が見られた. この結果から, HMPAO SPECTが高血流域での血流増加を過小評価している可能性は否定できないが, CCDを示している小脳半球のDIAMOX負荷による血流増加が対側の小脳半球よりも大きい可能性が強く示唆された. その場合diaschisis部において, 代謝の低下に伴い収縮している動脈がDIAMOXに対し正常部位よりも過剰に反応したとの仮説が考えられる. しかしこの仮説からは動脈の収縮が強いほどDIAMOXによる血管拡張が強いことが予想されるが, 今回の結果ではbaseline像での小脳半球の左右差の大きさとDIAMOX負荷による左右差の減少の程度には相関が見られなかった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Crossed cerebellar diaschisis, Acetazolamide, 99mTc-HMPAO, SPECT, Perfusion reserve. |
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| English |
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| Title | Acetazolamide Effect on Vascular Response in Crossed Cerebellar Diaschisis as Measured by 99mTc-HMPAO SPECT |
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| Subtitle | Original Articles |
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| Authors | Hitoshi TERADA*, Tatsuya GOMI**, Kyoko SASAKI**, Shogo MURAKAMI**, Setsu SATO**, Masashi NAGAMOTO**, Akira KUWAJIMA**, Yoshihiro HIRAMATSU**, Satoshi IWABUCHI***, Hirotsugu SAMEJIMA***, Nobuo YOSHII*** |
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| Authors(kana) | |
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| Organization | *Department of Neuroradiology, Neurological Institute, Tokyo Women's Medical College, **Second Department of Radiology, Toho University School of Medicine, ***Second Department of Neurosurgery, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 9 |
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| Page | 1075-1080 |
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| Year/Month | 1993/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We studied the effect of acetazolamine (DIAMOXR) on vascular response in areas with crossed cerebellar diaschisis (CCD) using consecutive 99mTc-hexamethyl-propyleneamine oxime (HMPAO) SPECT studies before and after DIAMOX administration with a subtraction method. Regions of interest were drawn over the bilateral cerebellar cortices and interhemispheric asymmetry indices (IAI) were obtained. Eleven of 14 patients with CCD at baseline showed decrease of IAI after DIAMOX administration. Although there is a possibility of underestimation of increase in perfusion in unaffected cerebellar hemisphere, this result suggests a greater increase in perfusion in the affected cerebellar hemisphere as compared with in the contralateral unaffected one and suggests more dilatation of the arterioles in areas with CCD post-DIAMOX than in areas without CCD. However nonsignificant correlation between IAI at baseline and difference of IAI from baseline to post-DIAMOX did not support the hypothesis of more dilatation post-DIAMOX of more constricted arterioles. |
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| Practice | Clinical medicine |
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| Keywords | Crossed cerebellar diaschisis, Acetazolamide, 99mTc-HMPAO, SPECT, Perfusion reserve. |
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