| Japanese |
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| Title | バセドウ病131I治療時の一回測定による有効半減期の推定法 |
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| Subtitle | 原著 |
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| Authors | 渡辺正好*, 伊藤國彦*, 三村孝*, 石川直文*, 井野英治*, 斉藤隆*, 辻仁*, 土屋武彦* |
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| Authors(kana) | |
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| Organization | *伊藤病院 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 9 |
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| Page | 1055-1062 |
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| Year/Month | 1993/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」バセドウ病に対する放射性ヨウ素 (以下131Iと略す) 治療に際しては, 131Iの甲状腺への吸収線量の算定が重要である. 有効半減期 (EHL) の測定は, 吸収線量の算出の際に摂取率, 甲状腺重量とともに欠くことのできない要因である. 入院, 通院可能な場合は, EHLの算出は数日間での数回の測定で可能である. しかし, 患者の事情によってはEHL測定のための数回の来院が不可能な場合もある. そこで今回われわれは, 一回の測定によってEHL推定を可能にする方法を検討した. 本法は, 131I投与後甲状腺摂取率と同時に有効半減期を推定しようとするものである. 131I 24時間摂取率測定時の甲状腺計数値と体計数値の比率を求め, その値を100倍したものを有効半減期指数 (EHL-index) とした. 実測したEHLとEHL-indexの関係は回帰直線および双曲線で表された. そこでさらに正確を期すために, 二曲線より新しい合成曲線を作図しEHL-indexからEHLを推定した. その結果, 実測したEHLとの間に±20%以内の誤差範囲内であれば検査時81.3%, 治療時83.7%の対象患者のEHLを推定できることが判明した. すなわち, この方法を用いれば一回測定でも近似的にEHLが推定でき, 治療時に一回測定しか行えなかった場合にも甲状腺への吸収線量の推定も可能となった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Effective half life, EHL-index, Body background, Graves' disease, 131I therapy. |
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| English |
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| Title | Estimation of Effective Half Life of 131I in Radioiodine Therapy for Graves' Disease Using a Single Radioiodine Uptake Measurement |
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| Subtitle | Original Articles |
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| Authors | Masayoshi WATANABE, Kunihiko ITO, Takashi MIMURA, Naofumi ISHIKAWA, Eiji INO, Takashi SAITOH, Hitoshi TSUJI, Takehiko TSUCHIYA |
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| Authors(kana) | |
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| Organization | Ito Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 9 |
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| Page | 1055-1062 |
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| Year/Month | 1993/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Calculation of the absorbed radioiodine dose in the thyroid gland is a very important factor in 131I therapy for Graves' disease. In 131I therapy, the measurement of the effective half life (EHL) of radioiodine in the thyroid gland is indispensable for calculating the absorbed radioiodine dose. In some cases, however, EHL cannot be calculated because repeated measurements of thyroid uptake cannot be done. So, the authors developed a new method to estimate EHL using a single radioiodine uptake measurement. The activity of intrathyroidal 131I (thyroid uptake) and that of the surrounding area of the shielded thyroid (body background) were measured at 24 hours after the administration of 131I. The ratio of the value of body background to thyroid uptake was calculated. This ratio was multiplied by 100 and the calculated value was named the EHL-index. The relationship between actual measured EHL and the EHL-index was expressed by a regression line and/or a hyperbola. For the purpose of obtaining more actual values of EHL using the EHL-index, the new combined curve was composed of the regression line and the hyperbola. As for the value of calculated EHL compared with that of actual measured EHL, about 80 percent of calculated EHL values were within acceptable error ranges. These results indicate that EHL can be estimated by a single measurement 24 hours after administration of 131I. This method should be very useful in the therapy of Graves' disease with 131I when the thyroid measurement is performed only one time. |
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| Practice | Clinical medicine |
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| Keywords | Effective half life, EHL-index, Body background, Graves' disease, 131I therapy. |
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