| Japanese |
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| Title | 甲状腺疾患のアイソトープ治療 - 放射性ヨウ素療法 - |
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| Subtitle | 総説 |
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| Authors | 日下部きよ子*, 牧正子* |
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| Organization | *東京女子医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 7 |
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| Page | 813-819 |
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| Year/Month | 1993/7 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」放射性ヨウ素である131Iは1942年以来, 患者への侵襲の少ない有効な治療法の一つとして甲状腺機能亢進症や甲状腺分化癌に使われている. それは131Iの放出するべータ線エネルギーと高い甲状腺特異性に由来する. 甲状腺機能亢進症における131I治療の特徴は症状の改善に時間がかかること, 晩発性甲状腺機能低下症の発生頻度が高いこと, そして確実な治療効果が得られることである. 131I治療後に正常機能を保つ例と晩発性機能低下症に至る例との間には, 治療前の甲状腺ホルモン値, 甲状腺重量, 131I投与量, 吸収線量, そして治療後の追跡検査データなどの因子に明らかな差は見られない. 甲状腺癌の転移の131I治療は, 40歳以下に見られる細かい散布性転移および潜在性転移では有効性が高いが, 骨転移ではシンチグラムで高い集積が見られても, 一時的または腫瘍の部分的効果に終わることが多い. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radioactive iodine therapy, 131I therapy, Hyperthyroidism, Metastases of thyroid carcinoma. |
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| English |
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| Title | Radionuclide Therapy of Thyroid Disease - Radioactive Iodine Therapy - |
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| Subtitle | |
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| Authors | Kiyoko KUSAKABE, Masako MAKI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Tokyo Women's Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 7 |
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| Page | 813-819 |
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| Year/Month | 1993/7 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Radioiodine, 131I, has been used for treatment of hyperthyroidism and metastases of well differentiated thyroid carcinoma since 1942. The use of 131I to treat hyperthyroidism and metastatic foci of thyroid cancer is one of the least invasive and most effective methods since the ionization produced by beta rays of 131I and it's high target-to-nontarget ratio are suitable. The feature of therapy with 131I on hyperthyroidism has a slow improvement of symptom, a high incidence of hypothyroidism, and an exact therapeutic effect. And, there is no significant difference between the patients with lateonset hypothyroidism and euthyroidism after 131I-therapy in the pretreatment factors, such as thyroid hormone levels, thyroid weight, 131I administration dose, and absorbed dose and also in the course of follow-up studies. On the treatment of metastases of thyroid cancer with 131I, it is very effective for the patients with fine or occult type of pulmonary metastases on chest XP, who are younger than 40 years old. On the other hand, the response to bone metastases of 131I therapy is limited to only a part of tumors and/or temporally in most cases though high grade of 131I accumulation is seen on scintigram. Both surgery and a curative dose of external irradiation should be combined with radioisotope therapy for the patients of bone metastases. |
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| Practice | Clinical medicine |
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| Keywords | Radioactive iodine therapy, 131I therapy, Hyperthyroidism, Metastases of thyroid carcinoma. |
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