| Japanese |
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| Title | 99mTc-MAG3による腎機能評価 - 123I-OIHおよび99mTc-DTPAとの比較 - |
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| Subtitle | 原著 |
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| Authors | 高山輝彦*, 油野民雄**, 秀毛範至**, 横山邦彦**, 道岸隆敏**, 孫保福**, 利波紀久**, 久田欣一**, 高畠利一***, 太田博真***, 友杉直久***, 小林健一*** |
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| Organization | *金沢大学医療短期大学部, **金沢大学医学部核医学科, ***第一内科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 7 |
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| Page | 753-760 |
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| Year/Month | 1993/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」腎・尿路疾患15症例を対象として, 99mTc-MAG3の臨床的有用性を検討した. 99mTc-MAG3イメージでは, 123I-OIHに比べて腹部大動脈や腸骨動脈および尿管が良好に描画され, 99mTc-DTPAに比べてバックグラウンド放射能の低い画質の良好な像が得られた. レノグラムの機能指標の検討では, 99mTc-MAG3と123I-OIH間で最大カウント数(Cmax)に対する20分のカウント数(C20)の比(C20/Cmax)に有意(P<0.05)な相関が認められた. さらに, 99mTc-MAG3の初期腎摂取率(X)と123I-OIHの初期腎摂取率(Y)の間には, 相関係数0.880と有意な相関が得られ, Y-1.16X-0.043の回帰式が導かれた. したがって, 99mTc-MAG3を用いてERPFを評価し得る可能性があると思われた. 以上より, 99mTc-MAG3は鮮明なイメージを提供し123I-OIHとよく似た動態を示すことから, 123I-OIHに代わり得ると思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MAG3, 123I-OIH, 99mTc-DTPA, ERPF, GFR. |
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| English |
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| Title | Evaluation of Renal Function Using 99mTc-MAG3 : Comparison with 123I-OIH and 99mTc-DTPA |
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| Authors | Teruhiko TAKAYAMA*, Tamio ABURANO**, Noriyuki SHUKE**, Kunihiko YOKOYAMA**, Takatoshi MICHIGISHI**, Bao-Fu SUN**, Norihisa TONAMI**, Kinichi HISADA**, Toshikazu TAKABATAKE***, Hiromichi OHTA***, Naohisa TOMOSUGI***, Kenichi KOBAYASHI*** |
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| Authors(kana) | |
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| Organization | *Allied Medical Profession, **Department of Nuclear Medicine, ***Department of Internal Medicine (I), Kanazawa University, School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 7 |
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| Page | 753-760 |
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| Year/Month | 1993/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The utility of 99mTc-mercaptoacetyltriglycine (MAG3) was studied clinically. In the renography obtained with 99mTc-MAG3, the abdominal aorta and the common iliac arteries were clearly visualized in the vascular phase. Due to less background activity and high target to background ratio, the quality of 99mTc-MAG3 image was superior to that of 123I-OIH or 99mTc-DTPA image. The parameters on the renogram including Tmax, T2/3, and T1/2were compared. The correlation of Tmax and T2/3 or T1/2 were not significant between 99mTc-MAG3 and 123I-OIH. Another parameter of C20/Cmax, where C20 and Cmax are renal activities at 20 min after injection and at Tmax respectively, showed an excellent correlation between 99mTc-MAG3 and 123I-OIH. Using C20/Cmax, pattern of renogram can be characterized numerically. Concerning about the relation between C20/Cmax and renogram pattern, standard renogram pattern showed the C20/Cmax value of less than 0.4, while hypofunctioning pattern showed more than 0.5. The correlation coefficient between the renal uptake of 99mTc-MAG3 and 123I-OIH was 0.880 with a correlation plot: "Y=1.16X-0.043", where X and Y represent renal uptake of 99mTc-MAG3 and 123I-OIH, respectively. It can be concluded that 99mTc-MAG3 is useful renal imaging agent as an alternative to 123I-OIH, in order to evaluate the proximal tubular function and calculate ERPF. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MAG3, 123I-OIH, 99mTc-DTPA, ERPF, GFR. |
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