Japanese
Title頭部外傷の123I-IMP SPECT - 定量による評価 -
Subtitle原著
Authors長町茂樹*, 西川卓志*, 小野真一*, 川崎建作**, 江口議八郎**, 陣之内正史***, 星博昭***, 二見繁美***, 大西隆***, 渡邊克司***
Authors(kana)
Organization*宮崎県立日南病院放射線科, **脳外科, ***宮崎医科大学放射線科
Journal核医学
Volume30
Number7
Page707-717
Year/Month1993/7
Article原著
Publisher日本核医学会
Abstract「要旨」急性期を過ぎた頭部外傷患者20例を対象にN-isopropyl-p[123I]iodoamphetamine(123I-IMP)を用いた脳血流SPECTを施行し, 同時期に施行されたX線CTと比較するとともに, Kuhlらのマイクロスフェアモデルを基本としたreference sampling methodを用いて局所脳血流量を測定した. CT所見との比較では, CT上の低吸収域の有無に関わらず全例にRIの集積低下があり, CT上の低吸収域より広範囲であった. またRIの集積低下を認めた部位のみならず, 視覚的には集積低下を認めない部位においても定量的に評価すると対照群と比較して有意に局所脳血流量の低下が認められた. 頭部外傷患者では急性期を過ぎた後, CT上に異常を認めなくても局所脳血流値が低下している場合があり, その評価に123I-IMP SPECTが有用であった.
Practice臨床医学：一般
Keywords123I-IMP, Head trauma, Regional cerebral blood flow, Reference sampling method.
English
TitleRegional Cerebral Blood Flow in the Patients with Closed-Head Injury Using 123I-IMP SPECT and Computed Tomography
SubtitleOriginal Articles
AuthorsShigeki NAGAMACHI*, Takushi NISHIKAWA*, Shinichi ONO*, Kensaku KAWASAKI**, Gihachiro EGUCHI**, Seishi JINNOUCHI***, Hiroaki HOSHI***, Shigemi FUTAMI***, Takashi OHNISHI***, Katsushi WATANABE***
Authors(kana)
Organization*Department of Radiology, Miyazaki Prefectural Nichinan Hospital, **Department of Neurosurgery, Miyazaki Prefectural Nichinan Hospital, ***Department of Radiology, Miyazaki Medical College
JournalThe Japanese Journal of nuclear medicine
Volume30
Number7
Page707-717
Year/Month1993/7
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]123I-IMP SPECT and CT were evaluated in 20 patients with closed-head injury. The detected focal lesions by both examinations were 36. Twenty lesions (55.6%) were seen on both CT and SPECT, and SPECT revealed larger abnormality than CT. Sixteen (44.4%) of 36 lesions were seen only on SPECT. Regional cerebral blood flow (r-CBF) of thirty-one focal lesions were quantified by reference sampling method and compared to r-CBF of the patients without neurological problem. r-CBF of 18 localized lesions accordant with low density area (LDA) on CT were significantly lower than those of 13 lesions seen only on SPECT. And r-CBF of both lesions were significantly lower than that of control patients. Regional cerebral blood flow on the areas with visually normal RI uptake were also significantly lower than that of control group. Regardless of CT findings, some disturbance of r-CBF was considered in patients with head trauma. Therefore the quantification of r-CBF with 123I-IMP SPECT was a useful method for evaluating functional change in those patients.
PracticeClinical medicine
Keywords123I-IMP, Head trauma, Regional cerebral blood flow, Reference sampling method.

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