| Japanese |
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| Title | 新しい99mTc標識心筋血流トレーサ (99mTc-Teboroxime) による心筋虚血の検出 - 201Tl心筋SPECTとの比較 - |
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| Subtitle | 短報 |
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| Authors | 宮川朋久*, 中居賢司**, 盛合直樹**, 荻生直徳*, 千葉誠*, 鎌田潤也*, 安達季之*, 笠月瑞子*, 加藤邦彦***, 高橋恒男***, 柳沢融***, 平盛勝彦* |
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| Authors(kana) | |
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| Organization | *岩手医科大学第二内科, **岩手医科大学臨床検査医学, ***岩手医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 6 |
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| Page | 669-674 |
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| Year/Month | 1993/6 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 狭心症患者8例を対象として, 新しい心筋血流トレーサである99mTc-Teboroximeを用いて運動負荷心筋SPECTを施行し, 心筋灌流異常検出に関し201Tl心筋SPECTと対比検討した. 両核種で心筋灌流異常と判定された領域・拡がりが一致したのは63%(10/16区域)で, 正常領域の一致率は83%(10/12区域)であった. 99mTc-Teboroxime心筋SPECTでは, 肝集積と重なる下壁領域で心筋灌流異常の判定が困難な例があった. また, 1例において施行したdipyridamole負荷99mTc-Teboroxime心筋SPECTによる心筋灌流異常は201Tl心筋SPECTの結果と同等であった. 今後, さらに検討を進めることにより, 半減期が短い特長を有する99mTc-Teboroximeは, 心筋梗塞症急性期の病態や再灌流療法に伴う心筋viabilityの評価に応用可能と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-Teboroxime, 201Tl SPECT, Myocardial ischemia |
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| English |
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| Title | Detection of Myocardial Ischemia by 99mTc-Teboroxime Myocardial SPECT : A Comparison with 201Tl Myocardial SPECT |
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| Subtitle | |
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| Authors | Tomohisa MIYAKAWA*, Kenji NAKAI**, Naoki MORIAI**, Junya KAMATA*, Toshiyuki ADACHI*, Makoto CHIBA*, Naonori OGIU*, Tamako KASAZUKI*, Kunihiko KATO***, Tsuneo TAKAHASHI***, Toru YANAGISAWA***, Katsuhiko HIRAMORI* |
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| Authors(kana) | |
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| Organization | *Second Department of Internal Medicine, **Department of Clinical Pathology, ***Department of Radiology, Iwate Medical University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 6 |
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| Page | 669-674 |
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| Year/Month | 1993/6 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Exercise myocardial SPECT using 99mTc-Teboroxime was performed and the regions of ischemic area were compared with 201Tl myocardial SPECT in 8 patients with coronary artery disease. All patients had no evidence of previous myocardial infarction, and underwent bicycle ergometer exercise according to a standardized multistage exercise protocol. At peak exercise, 555 MBq 99mTc-Teboroxime or 75 MBq 201Tl was injected intravenously. After termination of exercise, images were obtained with a gamma camera rotating through a 180° arc from 45° right anterior oblique to 45° left posterior oblique. The concordance of 99mTc-Teboroxime SPECT and 201Tl SPECT was 63% in ischemic region and 83% in normal region. Furthermore, one patient underwent dipyridamole infusion and 99mTc-Teboroxime SPECT was carried out. The images obtained by dipyridamole 99mTc-Teboroxime SPECT were equivalent to the images of exercise 201Tl SPECT. 99mTc-Teboroxime SPECT seems useful for the detection of the coronary artery disease. It was suggested that evaluation of the myocardial viability in acute phase of myocardial infarction can be possible by using 99mTc-Teboroxime SPECT. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-Teboroxime, 201Tl SPECT, Myocardial ischemia |
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