| Japanese |
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| Title | ドブタミン負荷タリウム心筋シンチグラフィの有用性および安全性 |
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| Subtitle | 原著 |
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| Authors | 今井嘉門*, 荒木康史**, 堀内孝一**, 斎藤頴**, 小沢友紀雄**, 八杉忠男** |
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| Authors(kana) | |
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| Organization | *埼玉県循環器病センター準備室, **日本大学医学部第二内科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 6 |
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| Page | 651-661 |
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| Year/Month | 1993/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 運動負荷に代わるドブタミン負荷タリウム(Tl)心筋シンチの有用性および安全性に関して133症例で検討した. ドブタミン負荷方法は, 10μg/kg/分より開始し, 3分ごとに10μg/kg/分ずつ増加し, 最大負荷濃度を40μg/kg/分とする方法である. ドブタミン負荷の終了時の濃度は25.5±7.8μg/kg/分, 負荷時間は7.3±2.3分で, 終了時の濃度が30μg/kg/分以上であった症例は65症例(49%)であった. ドブタミン負荷試験の除外対象を高血圧, 頻拍性の不整脈, 心房細動およびPTCA施行後短期間の症例とすると, 本法の副作用は高頻度であるも, 比較的安全な負荷方法であった. ドブタミン負荷Tl心筋シンチによる冠動脈病変の診断率は, 有病正診率:91%, 無病正診率:70%で, 運動負荷心筋シンチグラフィと同様に高値であった. ドブタミン負荷Tl心筋シンチは, 運動の不可能な患者にも行える負荷方法として比較的安全で, 有用な方法である. |
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| Practice | 臨床医学：一般 |
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| Keywords | Dobutamine stress, Thallium myocardial scintigraphy, Coronary artery disease |
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| English |
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| Title | Usefulness and Safety of Dobutamine Stress Thallium Myocardial Scintigraphy |
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| Subtitle | |
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| Authors | Kamon IMAI*, Yasushi ARAKI**, Kouichi HORIUCHI**, Satoshi SAITO**, Yukio OZAWA**, Tadao YASUGI** |
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| Authors(kana) | |
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| Organization | *Project Office for the Saitama Cardiovascular Center, **Second Department of Internal Medicine, Nihon University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 6 |
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| Page | 651-661 |
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| Year/Month | 1993/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Pharmaceutical stress test is performed for diagnosis of coronary artery disease in patients who can not perform exercise test. We studied whether high dose dobutamine stress test is useful and safe. Subjects consisted of 133 patients (pts) in dobutamine stress test and 45 pts in exercise test. Dobutamine stress test was initiated by 10μg/kg/min, followed by 10μg/kg/min increment every 3 minutes. Maximal dobutamine dose was 40μg/kg/min for 3 minutes. Endpoints of dobutamine stress were as follows: ST depression equal to or more than (>=) 0.2 mV: 30 pts, >= 75% predictive maximum heart rate: 20 pts, >= 20 mmHg systolic blood pressure fallen: 10 pts, 40μg/kg/min for 3 minutes: 10 pts, chest pain: 7 pts, pressure rate product (PRP) >= 25,000: 1 patient. Side effects of dobutamine stress test were as follows: palpitation: 52%, arhythmia: 13%, angina and dyspnea: 7%, headache: 6%. These symptoms were disappeared within 2 minutes. One patient, who performed dobutamine test 2 day after PTCA, had myocardial infarction. At peak of dobutamine stress test, systolic blood pressure, heart rate and PRP were increased similar to exercise test. However, diastolic blood pressure was not changed. The concentration at peak of dobutamine was 25.5+-7.8μg/kg/min. The duration of dobutamine stress test was 7.3+-2.3 minutes. The 65 patients (49%) need more than 20μg/kg/min of dobutamine which was maximal loading dose in previous reports. For diagnosis of coronary artery disease, sensitivity was 91% (31/34) and specificity was 70% (7/10). From these data, high dose dobutamine stress test is useful and relatively safe stress method for diagnosis of coronary disease. This stress test would be performed in patients who can not perform exercise test. |
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| Practice | Clinical medicine |
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| Keywords | Dobutamine stress, Thallium myocardial scintigraphy, Coronary artery disease |
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