| Japanese |
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| Title | 脳腫瘍動注療法における薬剤分布評価のための99mTc-HMPAO動注による脳SPECT |
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| Subtitle | 原著 |
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| Authors | 小須田茂*, 草野正一*, 青木茂樹**, 鈴木謙三**, 藤井博史**, 川上亮二**, 目崎高志**, 秋田佐喜子**, 中村治***, 設楽信行***, 寺田一志**** |
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| Authors(kana) | |
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| Organization | *防衛医科大学校放射線医学講座, **都立駒込病院放射線診療科, ***都立駒込病院脳外科, ****東邦大学医学部附属大橋病院放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 6 |
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| Page | 613-620 |
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| Year/Month | 1993/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 脳腫瘍術後患者17例に対して, 内頸動脈内動注療法時の脳内薬剤分布を評価するため, 99mTc-HMPAO 18.5MBqをカテーテルより選択的に動注し, 脳SPECTを撮像した. その結果, 99mTc-HMPAOによるSPECTは血管造影やDSAで予想された薬剤分布としばしば異なった分布を示した. 眼動脈分岐部遠位で連続注入した場合, 20%(2/10)が均一分布, 限局性集積を含めると80%(8/10)が不均一分布であったのに対し, パルス状に不連続注入(pulsatile infusion)した場合は全例, 均一分布であった(5/5). 眼動脈分岐部近位で連続注入した場合, 80%(4/5)がほぼ均一分布を示した. 不均一分布の原因は層流効果によると考えられ, pulsatile infusionにより層流効果を防止できると思われた. 結論として, 99mTc-HMPAOは動注療法における脳内薬剤分布を評価するためのトレーサとして有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-HMPAO, Brain tumor, Chemotherapy, Carotid artery, Drug delivery |
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| English |
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| Title | Brain SPECT by Intraarterial Infusion of 99mTc-HMPAO for Assessing the Cerebral Distribution of Carotid Artery Infusions in Patients with Brain Tumor |
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| Authors | Shigeru KOSUDA*, Shoichi KUSANO*, Shigeki AOKI**, Kenzo SUZUKI**, Hiroshi FUJII**, Ryoji KAWAKAMI**, Takashi MEZAKI**, Sakiko AKITA**, Osamu NAKAMURA***, Nobuyuki SHIDARA***, Hitoshi TERADA**** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, National Defense Medical College, **Department of Radiology, Tokyo Metropolitan Komagome Hospital, ***Department of Neurosurgery, Tokyo Metropolitan Komagome Hospital, ****Department of Radiology, Toho University Oohashi Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 6 |
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| Page | 613-620 |
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| Year/Month | 1993/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to assess the cerebral distribution of intracarotid chemotherapy, 17 postoperative patients with brain tumor underwent brain SPECT obtained by intraarterial infusion of 18.5 MBq of 99mTc-HMPAO. Injection methods were continuous (5.0 ml/min) or pulsatile infusion with supraor infraophthalmic catheterization. The findings obtained by brain SPECT were frequently different from those of angiography and/or DSA. In supraophthalmic catheterization with continuous infusion, only 2 of 10 studies (20%) had homogeneous distribution and 5 of them (50%) had maldistribution of 99mTc-HMPAO which appears in association with laminar flow effect. The remaining 3 studies showed localized distribution (two: tumor localization, one: healthy brain localization). On the other hand, all of 5 studies with pulsatile infusion had homogeneous distribution of 99mTc-HMPAO. In infraophthalmic catheterization, all but one of 5 studies had homogeneous distribution with continuous infusion. These results suggest that pulsatile infusion may be effective in eliminating maldistribution of 99mTc-HMPAO in supraophthalmic catheterization. In conclusion, we are convined that 99mTc-HMPAO is a useful intraarterial agent for assessing cerebral distribution of intracarotid chemotherapy. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-HMPAO, Brain tumor, Chemotherapy, Carotid artery, Drug delivery |
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