| Japanese |
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| Title | 血中1型プロコラーゲンC端プロペプチド (P1CP) の測定 |
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| Subtitle | 技術報告 |
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| Authors | 山本逸雄*, 高田政彦*, 大中恭夫*, 游逸明*, 山本裕子*, 浜津尚就**, 森田陸司* |
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| Authors(kana) | |
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| Organization | *滋賀医科大学放射線科, **放射線部 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 5 |
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| Page | 563-569 |
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| Year/Month | 1993/5 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」血中1型プロコラーゲンC端プロペプチド(P1CP)のRIAが開発され, その使用経験について報告する. 本アッセイは, ヒト1型プロコラーゲンのC端蛋白に対するウサギ抗体を用い, 分離法として抗ウサギヤギ抗体を共有結合させた小粒体を用いており, 手技が容易であり, 感度, 再現性などは良好であった. 骨転移症例における検討では, 骨硬化性転移を起こす前立腺癌例において高値を示した. また, 副甲状腺機能亢進症や甲状腺機能亢進症でも高値を示す症例がみられた. 他の骨代謝マーカーとの比較検討においても本アッセイは, 1型コラーゲンの合成の指標として, また骨形成の指標として, より優れたアッセイであると考えられた. 「I. はじめに」1型コラーゲンは最も多いタイプのコラーゲンであり, 皮膚, 骨, 腱, 象牙質のコラーゲンの主体をなすものである. 特に骨は代謝の盛んな臓器であり, 1型コラーゲンの代謝に最も関連をもっている. |
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| Practice | 臨床医学：一般 |
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| Keywords | Procollagen, Bone formation, P1CP, Radioimmunoassay, Osteocalcin. |
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| English |
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| Title | Measurement of Serum Concentration with Radioimmunoassay for Carboxyterminal Propeptide of Type 1 Procollagen |
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| Subtitle | |
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| Authors | Itsuo YAMAMOTO*, Masahiko TAKADA*, Yasuo OHNAKA*, Itsuaki YUU*, Yuuko YAMAMOTO*, Hisatoshi HAMAZU**, Rikushi MORITA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Central Radioisotope Division, Shiga University of Medical Science |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 5 |
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| Page | 563-569 |
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| Year/Month | 1993/5 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A radioimmunoassay kit for measurement of carboxyterminal propeptide of type 1 procollagen (P1CP) was developed and can be purchased commercially for clinical use. Using the kit, we measured serum concentration in healthy controls and in patients with bone metastasis and other various skeletal disorders. In healthy controls, serum concentration of P1CP ranged within 37-177 ng/ml under age 50, while in serum concentration of women over 50, it elevated upto 350 ng/ml. In patients with skeletal metastasis, in most of patients, it stayed within a normal range, whereas in patients with bone metastasis from prostatic cancer, it raised significantly. In some of patients with primary hyperparathyroidism or hyperthyroidism, serum concentration for P1CP was also elevated. In comparison with other serum bone metabolic markers such as osteocalcin or alkaline phosphatase, P1CP showed less occurrence of an elevation in patients with non-skeletal disease. Serum concentration of P1CP was not affected by renal function, while mild elevation was observed in patients with severely damaged liver diseases. In conclusion, the newly developed radioimmunoassay for P1CP was an excellent assay system and would provide us easily evaluation of type 1 collagen formation. |
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| Practice | Clinical medicine |
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| Keywords | Procollagen, Bone formation, P1CP, Radioimmunoassay, Osteocalcin. |
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