| Japanese |
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| Title | 99mTc-HMPAOを用いた脳血流の簡便な定量的評価法 - Patlak Plot法における手技的, 原理的考察 - |
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| Subtitle | 原著 |
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| Authors | 辻志郎*, 松田博史*, 秀毛範至*, 隅屋寿*, 利波紀久*, 久田欣一* |
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| Organization | *金沢大学医学部核医学教室 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 5 |
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| Page | 499-506 |
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| Year/Month | 1993/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-HMPAO静注によるRIアンジオグラフィを用いて脳血流を非侵襲的に定量評価する簡便な方法について検討した. トレーサの血液から脳への流入定数(Ku)を算出し, 客観的評価のため動脈ROIおよび脳ROIの大きさの比が10になるように補正し, 新しい脳血流指標(brain perfusion index, BPI)を求めた. 正常人41人の全脳のBPIは11.15±2.61であった. また年齢により二相性に緩やかに減少した. 脳血管障害患者103例における全脳の平均BPIは7.95±2.35で, 正常者より有意に低値を示した(P<0.001). さらに脳血管障害患者における左右比は, SPECT像よりもBPIが良好なコントラストを示した. 本法は非常に簡便でSPECTに付随して行うことができ, 日常診療において脳血流の定量評価に有用と考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-HMPAO, Radionuclide angiography, Brain perfusion, Cerebrovascular disease. |
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| English |
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| Title | Quantitative Analysis of Brain Perfusion Using Radionuclide Angiography with 99mTc-HMPAO |
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| Subtitle | Original Articles |
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| Authors | Shiro TSUJI, Hiroshi MATSUDA, Noriyuki SHUKE, Hisashi SUMIYA, Norihisa TONAMI, Kinichi HISADA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, Kanazawa University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 5 |
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| Page | 499-506 |
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| Year/Month | 1993/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A noninvasive simple method for quantitative radionuclide angiography with 99mTc-dl-hexamethyl propylene amine oxime (99mTc-HMPAO). The method of graphical analysis was employed for the evaluation of the uniderectional influx constant (Ku) from the blood to the brain for the tracer. The Ku values were standardized to represent objective and comparable values, brain perfusion indices (BPI), among studied subjects by setting the ratio of ROIbrain size to ROIaorta size to 10. The mean +- SD of the whole-brain BPI values for the 41 normal controls was 11.15 +- 2.61, and biphasic reduction with advancing age was observed. The mean of the whole-brain BPI of 7.95 with SD of 2.35 in 103 patients with cerebrovascular disorders was significantly lower than that in normal controls. The right to left ratio of BPI showed wider dynamic range than that of the total counts of SPECT. This technique is quite easy to apply as an adjunct to SPECT and may be helpful in the quantitative evaluation of brain perfusion in routine clinical studies. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-HMPAO, Radionuclide angiography, Brain perfusion, Cerebrovascular disease. |
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