Japanese
Title123I-IMP SPECTによる定量的脳血流量測定法 - 前腕加温静脈採血法 (WATER BATH法) による非侵襲的計測 -
Subtitle原著
Authors森脇博*, 松本昌泰**, 橋川一雄*, 奥直彦**, 岡崎裕**, 半田伸夫**, 木村和文****, 小塚隆弘*, 鎌田武信**, 西村恒彦*,***
Authors(kana)
Organization*大阪大学医学部中央放射線部, **第一内科, ***トレーサ情報解析, ****大阪船員保険病院内科
Journal核医学
Volume30
Number5
Page481-488
Year/Month1993/5
Article原著
Publisher日本核医学会
Abstract「要旨」123I-IMP SPECTによる定量的脳血流量測定法である持続動脈採血法を, 非侵襲かつ簡便化する目的で, 静脈を動脈の代用とする定量法を考案した. 対象は脳血管障害42例で, I群(非加温群)とII群(加温群)に分け, 後者をIIA群(電気ホットパックで加温した群)とIIB群(44℃のWATER BATHで加温した群)とに分けた. IMP静注後5分間, 動静脈持続採血を施行, 動脈血IMPに対する静脈血IMPの割合(%PR)を, 全血, 脂溶性, 水溶性成分について検討した. I群では症例間で%PRは大きく変動したが, II群, 特にIIB群で有意な平均%PRの上昇と変動の減少を認めた. IIB群にて全血, 脂溶性の%PRが一定と仮定した時の静脈法の動脈法に対する変動係数は, おのおの9.0%, 7.5%と良好な値を示した. 以上, WATER BATHによる加温静脈採血法にて, オクタノール抽出をしなくても脳への入力関数である動脈血IMP脂溶性成分を平均10%以内の誤差で推定可能であり, 同法にても非侵襲的定量測定が可能となると考えられた.
Practice臨床医学：一般
Keywords123I-IMP, SPECT, Regional cerebral blood flow, Quantitative measurement.
English
TitleQuantitative Assessment of Cerebral Blood Flow by 123I-IMP SPECT : Venous Sampling Method with Hand Warming in the Water Bath
SubtitleOriginal Articles
AuthorsHiroshi MORIWAKI*, Masayasu MATSUMOTO**, Kazuo HASHIKAWA*, Naohiko OKU**, Yutaka OKAZAKI**, Nobuo HANDA**, Kazufumi KIMURA****, Takahiro KOZUKA*, Takenobu KAMADA**, Tsunehiko NISHIMURA*,***
Authors(kana)
Organization*Division of Nuclear Medicine, **First Department of Internal Medicine, ***Division of Tracer Kinetics, Osaka University Medical School, ****Department of Internal Medicine, Osaka Seamen's Insurance Hospital
JournalThe Japanese Journal of nuclear medicine
Volume30
Number5
Page481-488
Year/Month1993/5
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]In order to establish a noninvasive, quantitative method for measuring regional cerebral blood flow (rCBF) by N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) SPECT, we attempted to employ continuous venous sampling instead of arterial sampling. Forty two patients with cerebrovascular diseases were classified into two groups, with (group II: n=35) and without (group I: n=7) hand warming. In group II, either hand was warmed, wrapping in a hot blanket (group IIA) or immersed in a 44℃ water bath (group IIB). In each patient, immediately after intravenous bolus injection of 222 MBq IMP, arterial and venous blood samples were collected continuously for 5 min from the radial artery and the cubital vein, respectively. By octanol extraction, IMP was divided into the unmetabolized and metabolized fraction. The ratio of 123I-IMP radioactivity of venous blood compared to arterial blood (pass ratio, referred as %PR) was calculated in three fractions, whole blood, unmetabolized, and metabolized fraction. By using these parameters, we assessed the possibility to estimate the amount of unmetabolized IMP fraction of arterial blood, usually used as an input function, from venous samples, In group I, %PR demonstrated a considerable variation between individuals (whole IMP, 47.5 +- 24.6% (mean +- SD) : unmetabolized IMP, 46.0 +- 24.5%: metabolized IMP, 51.8 +- 27.4%). In group II, especially in group IIB, both increase of %PR value and the decrease in variation (whole, 77.9 +- 5.6%: unmetabolized, 75.7 +- 5.7%: metabolized, 86.7 +- 8.7%) were observed, which permitted the further calculation based on the assumption that %PR value was constant in each IMP fraction (whole blood and unmetabolized fraction). The coefficient of variation (CV) of the difference between estimated arterial IMP radioactivity from venous samples and actual arterial IMP was 9.0% and 7.5%, based on the %PR value of each fraction, respectively. In conclusion, by using venous sampling coupled with a hand warming technique, we could estimate the arterial unmetabolized IMP radioactivity from venous samples in the good reliability about 90% or more, even without octanol extraction. This noninvasive method is quite useful to perform quantitative and serial measurements of rCBF by 123I-IMP SPECT.
PracticeClinical medicine
Keywords123I-IMP, SPECT, Regional cerebral blood flow, Quantitative measurement.

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