| Japanese |
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| Title | 99mTc-PPN 1011を用いた心筋灌流・心機能評価 - 臥位自転車エルゴメータを用いた運動負荷併用検査 - |
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| Subtitle | 短報 |
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| Authors | 汲田伸一郎*, 水村直*, 大石卓爾*, 隈崎達夫*, 佐野純子**, 山崎佳子**, 宗像一雄** |
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| Authors(kana) | |
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| Organization | *日本医科大学附属病院放射線科, **第一内科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 4 |
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| Page | 437-440 |
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| Year/Month | 1993/4 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心筋梗塞12例, 拡張型心筋症3例の計15例に対し, 99mTc-1, 2-bis[bis(2-ethoxyethyl)phosphino]ethane(99mTc-PPN 1011)を安静時仰臥位にて投与しファーストパスデータ(FP)を収集, 投与1時間後に心筋SPECTイメージの撮像を行った. FPよりLVEF(%), 心筋SPECTイメージよりseverity scoreの算出を行った. また心筋梗塞12例のうち7例には臥位エルゴメータを用いた運動負荷を行い, 負荷時のLVEF, severity scoreを算出した. FPより算出したLVEFは通常の心拍同期心プールシンチグラフィ(MUGA)より算出したLVEFと非常に良好な相関を示した(r=0.94;n=11). また運動負荷に伴うLVEFの低下(ΔLVEF)と心筋灌流低下値(Δseverity score)も良好な相関を示した(r=0.88, n=7). 99mTc-PPN 1011は標識も簡便であり, 心機能・心筋灌流評価を同時に行うことができ, 臨床的に有用な心筋血流トレーサであると思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-PPN 1011, Myocardial imaging, Left ventricular function, First-pass study. |
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| English |
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| Title | Assessment of Myocardial Perfusion and Left Ventricular Function with 99mTc-PPN 1011 |
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| Subtitle | |
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| Authors | Shin-ichiro KUMITA*, Sunao MIZUMURA*, Takuji OISHI*, Tatsuo KUMAZAKI*, Junko SANO**, Yoshiko YAMAZAKI**, Kazuo MUNAKATA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **First Department of Internal Medicine, Nippon Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 4 |
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| Page | 437-440 |
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| Year/Month | 1993/4 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]First-pass radionuclide angiography (FPRNA) was performed with the new myocardial perfusion agent 99mTc-1, 2, bis[bis(2-ethoxyethyl)phosphino]ethane(99mTc-PPN 1011) on stress and at rest. One hour after that, myocardial perfusion was counted by 99mTc-PPN 1011 SPECT. Left ventricular ejection fraction (LVEF) obtained by FPRNA correlated with that by multigated image with 99mTc-HSAD (r=0.94, n=11). The reduction of left ventricular function under the exercise (ΔLVEF) and the increase of severity score (ΔSeverity score) have a good relation (r=0.88) in 7 patients with prior myocardial infarction. Thus 99mTc-PPN 1011 appears to be an ideal radiopharmaceutical for evaluation of ventricular function and myocardial perfusion. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-PPN 1011, Myocardial imaging, Left ventricular function, First-pass study. |
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