| Japanese |
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| Title | 線条体における123I-IMPと99mTc-HMPAOによる脳血流SPECTの分布の違い - PETによる検討 - |
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| Subtitle | 原著 |
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| Authors | 大塚誠*,†, 一矢有一*, 桑原康雄*, 佐々木雅之*, 赤司祐子*, 吉田毅*, 福村利光*, 増田康治* |
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| Authors(kana) | |
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| Organization | *九州大学医学部放射線科, †現;九州大学生体防御医学研究所附属病院放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 4 |
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| Page | 389-395 |
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| Year/Month | 1993/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMPと99mTc-HMPAOによる脳血流SPECTを各種脳疾患10例において同時期に施行し, 大脳皮質部と線条体におけるそれぞれの薬剤の分布の違いをPETによる局所脳血流量と比較した. SPECT画像上の線条体, 大脳皮質各部, 小脳に計14個の関心領域を設定して, 右前頭葉皮質と各関心領域との比を, またPET脳血流量画像上でも同様の14部位と右前頭葉皮質との比を算出して比較した. 線条体を除いた領域におけるPETとの相関係数は123I-IMPが0.71, 99mTc-HMPAOが0.74であった. 線条体では他領域と明らかな差は見られなかったが, 123I-IMPはPETより低めの傾向にあり, また99mTc-HMPAOはPETとほぼ一致した. 視覚的にも同様の結果であった. しかし線条体血流低下の判定では, 123I-IMPはPETと全部位で一致したが, 99mTc-HMPAOは1例2部位で検出できなかった. 以上のことは両者の皮質部と線条体における分布パターンの違いが関与しているものと思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, 99mTc-HMPAO, 15O-PET, Striatal distribution. |
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| English |
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| Title | Difference in the Distribution of 123I-IMP and 99mTc-HMPAO in the Striatum - Comparison with 15O-PET - |
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| Subtitle | Original Articles |
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| Authors | Makoto OTSUKA, Yuichi ICHIYA, Yasuo KUWABARA, Masayuki SASAKI, Yuko AKASHI, Tsuyoshi YOSHIDA, Toshimitsu FUKUMURA, Kouji MASUDA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Faculty of Medicine, Kyushu University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 4 |
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| Page | 389-395 |
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| Year/Month | 1993/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Brain perfusion SPECT studies of 123I-IMP and 99mTc-HMPAO were performed in 10 patients with various brain disorders and the difference in the distribution of 123I-IMP and 99mTc-HMPAO in the cortices and striatum was compared with the cerebral blood flow by 15O-PET method. The ratios of the radioactivity in 14 ROIs of the cortices, striatum and cerebellum to that of the reference region or the right frontal cortex were compared among the 3 studies. The coefficient variance between 123I-IMP and PET was 0.71 and that between 99mTc-HMPAO and PET was 0.74 in the regions excluding the striatum. The striatal activity ratio in 123I-IMP was slightly less than those in 99mTc-HMPAO and PET which were close to each other. The visual activity in the striatum in 123I-IMP was also slightly less than those in 99mTc-HMPAO and PET. All the striatal lesions of decreased perfusion diagnosed by PET were observed in 123I-IMP, however 2 lesions were missed in 99mTc-HMPAO. This seems to be relevant to the difference in the distribution of 123I-IMP and 99mTc-HMPAO. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, 99mTc-HMPAO, 15O-PET, Striatal distribution. |
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