| Japanese |
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| Title | 塩化インジウムを用いる骨髄シンチグラフィにおける腎集積の検討 : 特に再生不良性貧血と骨髄異形成症候群について |
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| Subtitle | 原著 |
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| Authors | 小泉満*, 後藤政文**, 野村利治**, 亘理勉*, 斎藤憲治*** |
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| Authors(kana) | |
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| Organization | *獨協医科大学放射線科, **中央放射線部, ***第三内科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 4 |
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| Page | 377-387 |
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| Year/Month | 1993/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」塩化インジウムによる骨髄シンチグラムにおける腎集積について検討した. 症例は, 再生不良性貧血27例, 骨髄異形成症候群20例, その他10例であった. 腎集積と不飽和鉄結合能, 輸血の間に強い関係を認めた. シンチグラム上の腎集積と血液プール, 骨髄集積の間にも相関があった. 輸血により不飽和鉄結合能の低下をきたし, そのため静注された塩化インジウムがトランスフェリンと有効にキレートしないことが腎集積をきたす要因と考えられたが, 再生不良性貧血などの骨髄低形成も関与すると考えられた. また, 骨髄異形成症候群では, 腎集積のため骨髄が実際には正ないし過形成であるにもかかわらずシンチグラム上骨髄集積の低下を認めることがあり注意を要する. |
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| Practice | 臨床医学：一般 |
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| Keywords | 111InCl3 bone marrow scintigraphy, Renal uptake, Aplastic anemia, Myelodysplastic syndrome. |
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| English |
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| Title | Evaluation of Renal Uptake on 111InCl3 Bone Marrow Scintigraphy in Patients with Aplastic Anemia and Myelodysplastic Syndrome |
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| Subtitle | Original Articles |
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| Authors | Mitsuru KOIZUMI*, Masafumi GOTO**, Toshiharu NOMURA**, Tsutomu WATARI*, Kenji SAITO*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **The Central Service of Radiology, ***Third Department of Internal Medicine, Dokkyo Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 4 |
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| Page | 377-387 |
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| Year/Month | 1993/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]High renal uptake on bone marrow scan with indium-111 chloride is often shown in patients with bone marrow abnormality. We evaluated the renal uptake on bone marrow scan in 27 cases with aplastic anemia, 20 cases with myelodysplastic syndrome (MDS) and 10 cases with other diseases. The high renal uptake was observed in patients not only with aplastic anemia but also with MDS. The renal uptake correlated with blood transfusion units, unsaturated iron binding capacity (UIBC), blood pool imaging and bone marrow uptake. The renal uptake correlated with UIBC better than with the blood transfusion units. Following mechanism of the renal uptake is proposed that frequent blood transfusion makes low UIBC, and the low UIBC causes the failure to chelate indium with transferrin. The fast blood clearance of un-chelated indium via kidneys is followed. Hypoplastic bone marrow may also play an important role for the high renal uptake because all patients with the high renal uptake could not be explained by above mentioned mechanism. Caution should be paid to the scans with the high renal uptake because both aplastic anemia and MDS patients show the high renal uptake. |
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| Practice | Clinical medicine |
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| Keywords | 111InCl3 bone marrow scintigraphy, Renal uptake, Aplastic anemia, Myelodysplastic syndrome. |
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