| Japanese |
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| Title | Dipyridamole負荷ファーストパス法による左室早期拡張能の評価 - 運動負荷法との比較 - |
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| Subtitle | 原著 |
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| Authors | 宍戸稔聡*, 野々木宏*, 下永田剛**, 宇都宮正範*, 伊藤彰*, 土師一夫*, 西村恒彦** |
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| Authors(kana) | |
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| Organization | *国立循環器病センター内科心臓部門, **放射線診療部 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 4 |
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| Page | 363-369 |
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| Year/Month | 1993/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Dipyridamole負荷と運動負荷が虚血心の左室拡張能に及ぼす影響について検討するため, 多結晶型ガンマカメラ(SIM-400)を用い, 狭心症32例(AP群)と健常者14例(N群)にdipyridamole負荷または運動負荷前後にファーストパス法(first pass radionuclide angiocardiography)を施行し, 左室早期拡張能を解析した. 運動負荷ではAP群, N群とも左室拡張早期1/3充満分画(FF 1/3)の減少と左室拡張早期1/3平均充満速度(MFR 1/3)が増加したが, 両群間に差はみられなかった. これに対し, dipyridamole負荷ではN群のFF 1/3, MFR 1/3は有意な変化を示さなかったが, AP群ではFF 1/3, MFR 1/3のいずれも有意に低下し, 両群間で明らかに異なる動態を示した. 以上から, 左室早期拡張能障害の検出には, 運動負荷法に比べてdipyridamole負荷法の方がより鋭敏な方法であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | First pass radionuclide angiocardiography, Dipyridamole, Left ventricular diastolic function, Coronary artery disease. |
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| English |
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| Title | Evaluation of Left Ventricular Early Diastolic Function by First Pass Radionuclide Angiocardiography after Dipyridamole Infusion in Patients with Coronary Artery Disease - Comparison with Exercise Test - |
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| Subtitle | Original Articles |
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| Authors | Toshiaki SHISHIDO*, Hiroshi NONOGI*, Tsuyoshi SHIMONAGATA**, Masanori UTSUNOMIYA*, Akira ITO*, Kazuo HAZE*, Tsunehiko NISHIMURA** |
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| Authors(kana) | |
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| Organization | *Division of Cardiology, Department of Internal Medicine, **Department of Radiology, National Cardiovascular Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 4 |
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| Page | 363-369 |
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| Year/Month | 1993/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate the left ventricular early diastolic function after dipyridamole infusion or during exercise, the first pass radionuclide angiocardiography (FPRA) by a multicrystal gamma camera (SIM-400) was performed in 32 patients with coronary artery disease (CAD) and 14 normal subjects. Dipyridamole was administered intravenously (0.56 mg/kg in 4 min). The first third filling fraction (FF 1/3) and the first third mean filling rate (MFR 1/3) were calculated from the time-activity curve. FF 1/3 decreased and MFR 1/3 increased in both normal subjects and patients with CAD during exercise. After dipyridamole infusion, FF 1/3 and MFR 1/3 unchanged in normal subjects, in contrast, FF 1/3 and MFR 1/3 decreased in patients with CAD. Thus, dipyridamole infusion FPRA is more sensitive method to detect early diastolic dysfunction in patients with CAD than FPRA during exercise. |
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| Practice | Clinical medicine |
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| Keywords | First pass radionuclide angiocardiography, Dipyridamole, Left ventricular diastolic function, Coronary artery disease. |
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