| Japanese |
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| Title | 虚血性心疾患における99mTc-tetrofosmin心筋シンチグラフィの有用性について - 201Tl心筋シンチグラフィとの対比 - |
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| Subtitle | 原著 |
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| Authors | 足立至*, 杉岡靖*, 田中康敬*, 小倉康晴*, 中田和伸*, 難波隆一郎*, 辰吉光*, 西垣洋*, 末吉公三*, 楢林勇*, 田本重美**, 大竹義章*** |
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| Authors(kana) | |
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| Organization | *大阪医科大学放射線科, **第一内科, ***第三内科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 4 |
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| Page | 351-362 |
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| Year/Month | 1993/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」新しい心筋イメージング製剤である99mTc-tetrofosminによる心筋シンチグラフィと201Tl心筋シンチグラフィを同一症例に施行し, 対比検討した. 対象は虚血性心疾患が疑われた10症例で, 方法はplanar像, SPECT像を撮像し, 99mTc-tetrofosmin心筋シンチグラフィではさらにゲートSPECTを施行した. Planar像では201Tl心筋シンチグラフィに比べ, 99mTc-tetrofosmin心筋シンチグラフィでは肺野バックグラウンドが低く明瞭な心筋像をとらえることができた. SPECT像での病変部位の検出については多くの症例で一致し, また不一致例においても201Tl心筋シンチグラフィとは異なる有用な所見であった. ゲートSPECT像は全例撮像でき, 良好な画像を得ることができ, またpercent wall thickeningなどの指標も算出することができ, 心筋壁運動の評価の一助になるものと考えられた. 以上から99mTc-tetrofosminによる心筋シンチグラフィは今後とも有用になるものと期待される. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-tetrofosmin, 201Tl, Myocardial scintigraphy, Gated SPECT. |
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| English |
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| Title | Clinical Efficacy of 99mTc-Tetrofosmin Myocardial Scintigraphy - Comparison to 201Tl Myocardial Scintigraphy - |
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| Subtitle | Original Articles |
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| Authors | Itaru ADACHI*, Yasushi SUGIOKA*, Yasunori TANAKA*, Yasuharu OGURA*, Yasunobu NAKATA*, Ryuuichiro NAMBA*, Yoshimitsu TATSU*, Hiroshi NISHIGAKI*, Kouzou SUEYOSHI*, Isamu NARABAYASHI*, Shigemi TAMOTO**, Yoshi-aki OHTAKE*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **First Department of Internal Medicine, ***Third Department of Internal Medicine, Osaka Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 4 |
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| Page | 351-362 |
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| Year/Month | 1993/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]99mTc-tetrofosmin is a lipophilic, cationic diphosphine which has been developed for myocardial imaging. We examined 9 patients with ischemic heart disease including 3 angina pectoris (AP), 4 old myocardial infarction (OMI), 1 AP with OMI and 1 syndrome X. One patient was examined before and after operation. 370 MBq of 99mTc-tetrofosmin was injected during exercise and 740 MBq at rest. And 74 MBq of 201Tl myocardial exercise and redistribution scintigraphy was also performed to compare with 99mTc-tetrofosmin myocardial scintigraphy. SPECT, multiple gated SPECT and anterior planar images were obtained in all cases. We calculated percent wall thickening (%WT) using multiple gated SPECT images. There was a decreased lung uptake in 99mTc-tetrofosmin planar images compared to 201Tl myocardial scntigraphy. Liver and Biliary system uptake in 99mTc-tetrofosmin images was decreased with intake of milk. Segmental comparison of SPECT images showed an agreement in 9/10 of the segment between 201Tl and 99mTc-tetrofosmin. We could obtain excellent quality of multiple gated SPECT images in all patients. We could calculate percent wall thickening (%WT) in all patients. We conclude that 99mTc-tetrofosmin myocardial scintigraphy should provide usefulness for detection of ischemic myocardium as same as 201Tl myocardial scintigraphy, although the biologic characteristics of two agents were different. These data and excellent quality of multiple gated SPECT images suggest that 99mTc-tetrofosmin is a new 99mTc agent for evaluation of patients with ischemic heart disease. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-tetrofosmin, 201Tl, Myocardial scintigraphy, Gated SPECT. |
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