| Japanese |
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| Title | ポジトロンCTによる心筋代謝血流評価の動向 |
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| Subtitle | 総説 |
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| Authors | 大嶽達*, 横山郁夫**, 芹沢剛**, 西川潤一*, 佐々木康人* |
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| Organization | *東京大学医学部放射線科, **東京大学医学部第二内科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 3 |
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| Page | 331-339 |
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| Year/Month | 1993/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 ポジトロンCTが心筋に応用されはじめて以来, 心筋血流の評価, 心筋糖代謝の評価, 心筋脂肪酸代謝, 酸素代謝の評価などが行われてきた. 特に血流と糖代謝を測定し, 代謝血流ミスマッチの所見から心筋viabilityを評価できることが臨床的に非常に重要とされてきた. このような研究は従来定性的なものが多かったが, 近年動脈採血をしない非侵襲的定量が可能となり, 糖代謝の定量や, 血流予備能の直接測定が日常臨床でも可能となってきた. われわれは, 114症例で空腹時, 糖負荷時, インシュリンクランプ時に心筋糖消費量を定量し, それと血中インシュリン値やFFA値との関係, 各条件での正常値, 心筋各部位での差などを検討した. そして心筋viabilityの評価にいかなる条件のFDG検査が適当か, Schelbertの糖負荷またはインシュリン皮下注を勧める考えを紹介し, それに対するわれわれの空腹または軽いインシュリンクランプ条件が適切との考察を示した. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron emission computed tomography (PET), Myocardial blood flow, Fluorine-18 fluorodeoxyglucose (FDG), Coronary artery disease (CAD), Diabetes mellitus (DM) |
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| English |
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| Title | The Recent Studies of Myocardial Blood Flow and Metabolism by Using Positron Emission Computed Tomography |
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| Subtitle | |
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| Authors | Tohru OHTAKE*, Ikuo YOKOYAMA**, Takashi SERIZAWA**, Jun-ichi NISHIKAWA*, Yasuhito SASAKI* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Faculty of Medicine, University of Tokyo, **Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 3 |
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| Page | 331-339 |
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| Year/Month | 1993/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Since the application of positron emission computed tomography (PET) for myocardium, the evaluation of myocardial blood flow, glucose metabolism, fatty acid metabolism, oxygen consumption and etc. has been performed. Especially, it has been regarded very important clinically to evaluate myocardial viability from the mismatch of myocardial glucose metabolism and blood flow. Many early myocardial PET studies were qualitative, while recently noninvasive quantitation method without arterial blood sampling has become possible in quantitating myocardial glucose metabolism or myocardial blood flow reserve. We quantitated regional myocardial glucose utilization rates (rMGU) in 114 cases during fasting, oral glucose loading, or insulin clamp to. study the relation between rMGU and plasma insulin value or FFA value, the normal rMGU value during each condition and the difference of rMGU among each part of myocardium. And as to the question in which condition of FDG study was appropriate to evaluate myocardial viability, we introduced the opinion of Schelbert for oral glucose loading or insulin injection method and presented our opinion for fasting or mild insulin clamp. |
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| Practice | Clinical medicine |
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| Keywords | Positron emission computed tomography (PET), Myocardial blood flow, Fluorine-18 fluorodeoxyglucose (FDG), Coronary artery disease (CAD), Diabetes mellitus (DM) |
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