| Japanese |
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| Title | 乳癌の新しい腫瘍マーカーCA549測定の基礎的検討および臨床的有用性の評価 |
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| Subtitle | 技術報告 |
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| Authors | 山口敦子*, 牛込真理恵*, 今井俊幸*, 大竹英則*, 五十嵐均*, 羽鳥昇*, 冨吉勝美*, 井上登美夫*, 遠藤啓吾* |
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| Authors(kana) | |
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| Organization | *群馬大学医学部核医学科・中央放射線部 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 3 |
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| Page | 317-322 |
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| Year/Month | 1993/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 モノクローナル抗体を利用した乳癌の腫瘍マーカーCA549測定用IRMAキット「BL-CA549」の基礎的, 臨床的検討を行うとともに, CA15-3抗原との関係を検討した. CA549測定の再現性, 希釈試験などは満足すべき結果が得られ, 乳癌患者で高値を示す症例が多く認められた. 血中CA549濃度はCA15-3濃度と強く相関した. CA549, CA15-3の測定に用いる125I-標識トレーサ, 抗体固相化ビーズを組み合わせた4つのアッセイを行ったところ, いずれのアッセイでもキット添付のCA15-3抗原の測定が可能であった. またCA549に対するモノクローナル抗体は125I-標識抗CA15-3抗体の抗原への結合を完全に阻害した. これらの結果はCA549とCA15-3がほぼ同一の性状の抗原であることを示唆する. 「I. はじめに」 米国では乳癌が女性の悪性腫瘍の第1位を占めているが, わが国でも近年乳癌の増加が著しい. |
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| Practice | 臨床医学：一般 |
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| Keywords | CA549, CA15-3, Breast cancer, Immunoradiometric assay |
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| English |
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| Title | Basic Study of CA549, a New Tumor Marker for Breast Cancer, and Evaluation of Its Clinical Usefulness |
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| Subtitle | |
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| Authors | Atsuko YAMAGUCHI*, Marie USHIGOME*, Toshiyuki IMAI*, Hidenori OTAKE*, Hitoshi IGARASHI*, Noboru HATORI*, Katsumi TOMIYOSHI*, Tomio INOUE*, Keigo ENDO* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine and Central Radiation Center, School of Medicine, Gunma University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 3 |
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| Page | 317-322 |
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| Year/Month | 1993/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We performed basic and clinical studies of IRMA kits for serum CA549 antigen and examined the immunological correlation between CA549 and CA15-3 antigens. Satisfactory results were obtained in the basic studies of CA549 assays, such as the reproducibility and the dilution test. Many patients with breast cancer had elevated serum CA549 concentrations and significant correlation was observed between serum CA549 and CA15-3 values. Anti-CA549 antibody completely inhibited the binding of 125I-labeled anti-CA15-3 antibody to its antigens. These results suggest that CA549 and CA15-3 antigens have similar immunological characteristics. |
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| Practice | Clinical medicine |
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| Keywords | CA549, CA15-3, Breast cancer, Immunoradiometric assay |
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