| Japanese |
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| Title | 123I-IMP SPECTにて局所脳血流の経過観察を行った前頭葉症候群の一例 |
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| Subtitle | 症例報告 |
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| Authors | 内田佳孝*, 児玉和宏**, 蓑島聡***, 池田智明**, 宇野公一***, 安西好美***, 北方勇輔*, 有水昇*** |
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| Authors(kana) | |
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| Organization | *君津中央病院放射線科, **千葉大学医学部精神科神経科, ***千葉大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 3 |
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| Page | 303-311 |
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| Year/Month | 1993/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 N-isopropyl-p-[I-123]iodoamphetamineおよびSPECTを用いた局所脳血流測定により, 経過観察を行い得た前頭葉症候群の症例において, 興味ある所見を得たので文献的考察を加えて報告する. 症例は58歳男性で, 路上に倒れているところを発見されて入院した. 入院後, 無為・好褥を認め, 摂食・排泄も自ら行わず, 発動性が減退していた. また性格変化(諧謔症)も認められた. これらの所見は前頭葉症候群と考えられた. MRIでは入院直後に右前頭葉前方に硬膜下血腫を認めた以外に明らかな異常所見は認めなかった. 入院後1年6か月にわたり計6回のSPECT検査を行った. 初回検査で異常を認めなかった両側前頭葉の血流が経過に従い徐々に低下した. 経過中, 性格変化(諧謔症)には箸変を認めなかったが, 自発性の低下は改善した. これらの所見は, SPECTにより測定された局所脳血流の変化が, 必ずしも全ての精神症状の変化と一致しているとは限らないという点において, 患者の病態を脳血流変化という一側面からとらえる限界を示唆したと思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP brain SPECT, Frontal lobe syndrome |
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| English |
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| Title | A Case of Frontal Lobe Syndrome Followed by Serial 123I-IMP SPECT |
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| Subtitle | Case Report |
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| Authors | Yoshitaka UCHIDA*, Kazuhiro KODAMA**, Satoshi MINOSHIMA***, Tomoaki IKEDA**, Kimiichi UNO***, Yoshimi ANZAI***, Yuusuke KITAKATA*, Noboru ARIMIZU*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Kimitsu Central Hospital, **Department of Neuropsychiatry, Chiba University, School of Medicine, ***Department of Radiology, Chiba University, School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 3 |
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| Page | 303-311 |
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| Year/Month | 1993/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Single photon emission computed tomography (SPECT) studies with N-isopropyl-p-[123I]iodoamphetamine (IMP) were performed in a 58-year-old man with frontal lobe syndrome. He had abulia and personality changes suggesting frontal lobe impairment. Six follow-up SPECT studies were conducted during 18 months from the onset. On the first scan, no abnormal pattern of regional cerebral blood flow (rCBF) was found. On the second scan, a mild reduction of rCBF was observed in bilateral frontal lobes. Through the third to sixth scans, a progressed reduction of rCBF in bilateral frontal lobes was confirmed by a semiquantitative regions-of-interest analysis. Contrarily, abulia was improved, and personality change was not progressed during that period. Magnetic resonance imaging on admission revealed only a small subdural hematoma and high intensity areas in the right frontal lobe, which were resolved at the time of the sixth SPECT scan. It is suggested that rCBF studies by SPECT is not necessary concordant with psychiatric symptoms, and has possible limitations in pathophysiological evaluation for psychiatric disorders. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP brain SPECT, Frontal lobe syndrome |
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