| Japanese |
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| Title | 肝胆道疾患における99mTc-DTPA-galactosyl-serum-albumin (GSA) の臨床応用 |
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| Subtitle | 技術報告 |
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| Authors | 大野耕一*, 伊藤和夫**, 永尾一彦**, 加藤紘之*, 奥芝知郎*, 佐藤正文*, 富山光広*, 平口悦郎*, 田辺達三* |
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| Organization | *北海道大学医学部第二外科学教室, **北海道大学医学部核医学教室 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 2 |
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| Page | 217-224 |
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| Year/Month | 1993/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」10例の慢性肝疾患患者を対象として99mTc-GSA血中動態および肝摂取率について各種肝機能パラメータと比較検討し, また, 画像上の評価を試みた. 血中消失率のパラメータであるHH15は肝硬変群では0.81±0.05, 非肝硬変群で0.64±0.10, 肝摂取率のパラメータであるLHL15は肝硬変群で0.79±0.04, 非肝硬変群で0.91±0.06であり, 両者とも2群間に有意差が示された. 2コンパートメントモデルを用いた早期血中消失係数(KH1)および肝摂取係数(KL)はいずれも肝硬変および非肝硬変群で有意差が示され, HH15対KH1, LHL15対KLに有意な相関が認められた. 99mTc-GSAと従来の肝機能評価因子との間にも良好な相関を認めたが, 99mTc-HSAの相対的門脈/総肝血流比との間には有意な相関が示されなかった. また, GSAでは良好な肝描出が得られた. 以上から99mTc-GSA肝シンチグラフィは従来の肝機能評価とは異なる形態的および機能的肝評価法として期待される. |
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| Practice | 臨床医学：一般 |
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| Keywords | Technetium-99m-DPTA-galactosyl human serum albumin (99mTc-GSA), Technetium-99m-DPTA human serum albumin (99mTc-HSA), Liver function, Asialoglycoprotein receptor, Hepatic blood flow |
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| English |
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| Title | Clinical Application of 99mTc-DTPA-galactosyl Serum Albumin in Hepatobiliary Disease |
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| Subtitle | Summary |
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| Authors | Kohichi OHNO*, Kazuo ITOH**, Kazuhiko NAGAO**, Hiroyuki KATOH*, Tomoo OKUSHIBA*, Masafumi SATOH*, Mitsuhiro TOMIYAMA*, Etsuo HIRAGUCHI*, Tatsuzo TANABE* |
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| Organization | *Second Department of Surgery, **Department of Nuclear Medicine, Hokkaido University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 2 |
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| Page | 217-224 |
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| Year/Month | 1993/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | A clinical study with 99mTc-DTPA-galactosyl serum albumin (99mTc-GSA) was performed in 10 patients with hepatobiliary disease. In this study, scintigraphic data and images with 99mTc-GSA were compared with several serological liver function tests, the hepatic blood perfusion index and image quality using 99mTc-DTPA-human serum albumin (99mTc-HSA). Dynamic and serial hepatic images were obtained over a 20 min period after 99mTc-GSA injection, and time activity curves from the heart and liver were generated. The blood clearance index (HH15), and the hepatic uptake index (LHL15) were calculated from each curve of the heart and liver, respectively. In addition, using two compartment fitting, the blood clearance (KH1, KH2) index was calculated, and using exponential fitting, the hepatic uptake index (KL) was calculated. The mean HH15 in LC group and non-LC group was 0.81 +- 0.05, 0.64 +- 0.10, respectively. The mean LHL15 in LC group and non-LC group was 0.79 +- 0.04, 0.91 +- 0.06, respectively. There were significant differences between non-LC group and LC group in HH15, and LHL15, KH1, and KL. There were also significant correlations of KH1 with HH15, and KL with LHL15. Parameters of 99mTc-GSA showed significant correlations with various liver functions. 99mTc-GSA scintigraphy showed clearer liver images in hepatobiliary diseases than 99mTc-HSA. These results suggest that 99mTc-GSA scintigraphy is useful in estimating preserved liver function and hepatic morphology. |
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| Practice | Clinical medicine |
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| Keywords | Technetium-99m-DPTA-galactosyl human serum albumin (99mTc-GSA), Technetium-99m-DPTA human serum albumin (99mTc-HSA), Liver function, Asialoglycoprotein receptor, Hepatic blood flow |
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