| Japanese |
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| Title | Sjogren 症候群における唾液腺シンチグラフィの有用性の再評価 |
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| Subtitle | 原著 |
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| Authors | 小須田茂*, 鈴木謙三**, 川上亮二**, 秋田佐喜子**, 目崎高志**, 猪熊茂子***, 久保敦司**** |
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| Organization | *防衛医科大学校放射線医学講座, **都立駒込病院放射線診療科, ***都立駒込病院内科, ****慶應義塾大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 2 |
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| Page | 161-170 |
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| Year/Month | 1993/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」シェーグレン症候群(SjS)が疑われた95例に対し, 経時的唾液腺シンチグラフィを施行し, SjS診断基準と対比した. 時間放射能曲線をN, M1, M2, Fの4つのパターンに分類できた. SjS確実例では4腺がすべてF型を示す典型例は少なく(3/38, 8%), 4腺がそれぞれ異なったパターンを示した. F型またはM2型を呈した唾液腺が全腺の68.5%(98/143)を占め, 4腺のうち, 2腺以上がFまたはM2型を示した場合をSjSの診断基準にすると, sensitivity, specificity, accuracy はそれぞれ, 82.9%, 59.5%, 70.8%であった. 唾液腺摂取率ではSjS確実例と対象群間に有意差(耳下腺 p<0.05, 顎下腺 p<0.01)がみられたが, SjS確実例, SjS疑い例, 慢性唾液腺炎の各群間には有意差は認めなかった. 結論として, 時間放射能曲線のパターン分類がSjS診断におけるスクリーニング検査として簡便で有用な方法であることが再評価された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Sjogren's syndrome, Salivary gland, Sialoscan, Collagen disease, 99mTc-pertechnetate |
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| English |
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| Title | Reassessment of Usefulness of Salivary Scintigraphy in Diagnosis of Sjogren's Syndrome |
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| Subtitle | Summary |
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| Authors | Shigeru KOSUDA*, Kenzo SUZUKI**, Ryoji KAWAKAMI**, Sakiko AKITA**, Takashi MEZAKI**, Shigeko INOKUMA***, Atsushi KUBO**** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, National Defense Medical College, **Department of Radiology, Tokyo Metropolitan Komagome Hospital, ***Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, ****Department of Radiology, Keio University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 2 |
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| Page | 161-170 |
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| Year/Month | 1993/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Dynamic salivary scintigraphy using 99mTcO4- was performed in 95 patients (a total of 366 glands) suspected of Sjogren's syndrome (SjS) and the results were compared with SjS diagnostic criteria by the Japanese Welfare Ministry. Time-activity curve of ROI created over each salivary gland was classified into four patterns, that is, N, M1, M2, F pattern, depending upon trapping, accumulation and secretion response to the tartaric acid. In definite SjS patients, most of the patients had different patterns in the four glands, and classical F (flat) pattern in all of the four glands was uncommon (3/38, 8%). F and/or M2 (no response to secretary stimulation) patterns were seen in 68.5% (98/143) of the all glands. Provided that F and/or M2 patterns in 2 or more glands is scintigraphic criteria for diagnosis of SjS, sensitivity, specificity and accuracy were 82.9%, 59.5%, 70.8%, respectively. As for salivary uptake of 99mTcO4-, there is a significant difference between the patients with definite SjS and control subjects (parotis p < 0.05, submandibular gland p < 0.01), but there is no significant difference among the patients with definite SjS, suspected SjS and chronic sialoadenitis. In conclusion, the four patterns classification may have potential in screening patients with SjS. |
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| Practice | Clinical medicine |
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| Keywords | Sjogren's syndrome, Salivary gland, Sialoscan, Collagen disease, 99mTc-pertechnetate |
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